| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C19orf53 | C19orf67 | ENSP00000465432 | ENSP00000449137 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family. | 0.584 |
| C19orf53 | C9orf16 | ENSP00000465432 | ENSP00000362085 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | 0.472 |
| C19orf53 | CCDC124 | ENSP00000465432 | ENSP00000471455 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages. Belongs to the CCDC124 family. | 0.581 |
| C19orf53 | COPS9 | ENSP00000465432 | ENSP00000304147 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | COP9 signalosome complex subunit 9; [Isoform 1]: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD k [...] | 0.538 |
| C19orf53 | NDUFA11 | ENSP00000465432 | ENSP00000389160 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.528 |
| C19orf53 | NDUFB7 | ENSP00000465432 | ENSP00000215565 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.500 |
| C19orf53 | POLR2J | ENSP00000465432 | ENSP00000292614 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | DNA-directed RNA polymerase II subunit RPB11-a; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). | 0.584 |
| C19orf53 | PSMB3 | ENSP00000465432 | ENSP00000483688 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | Proteasome subunit beta type-3; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | 0.626 |
| C19orf53 | RNF181 | ENSP00000465432 | ENSP00000306906 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | E3 ubiquitin-protein ligase RNF181; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. | 0.479 |
| C19orf53 | SERF2 | ENSP00000465432 | ENSP00000387187 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | Small EDRK-rich factor 2; Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates. Belongs to the SERF family. | 0.480 |
| C19orf67 | C19orf53 | ENSP00000449137 | ENSP00000465432 | UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family. | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | 0.584 |
| C9orf16 | C19orf53 | ENSP00000362085 | ENSP00000465432 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16. | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | 0.472 |
| CCDC124 | C19orf53 | ENSP00000471455 | ENSP00000465432 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages. Belongs to the CCDC124 family. | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | 0.581 |
| CCDC124 | NDUFB7 | ENSP00000471455 | ENSP00000215565 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages. Belongs to the CCDC124 family. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.423 |
| COPS9 | C19orf53 | ENSP00000304147 | ENSP00000465432 | COP9 signalosome complex subunit 9; [Isoform 1]: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD k [...] | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | 0.538 |
| NDUFA11 | C19orf53 | ENSP00000389160 | ENSP00000465432 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | 0.528 |
| NDUFA11 | NDUFB7 | ENSP00000389160 | ENSP00000215565 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.999 |
| NDUFB7 | C19orf53 | ENSP00000215565 | ENSP00000465432 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy. | 0.500 |
| NDUFB7 | CCDC124 | ENSP00000215565 | ENSP00000471455 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages. Belongs to the CCDC124 family. | 0.423 |
| NDUFB7 | NDUFA11 | ENSP00000215565 | ENSP00000389160 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.999 |
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