STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF404Zinc finger protein 404; May be involved in transcriptional regulation. (552 aa)    
Predicted Functional Partners:
FLACC1
Flagellum-associated coiled-coil domain-containing protein 1; Flagellum associated containing coiled-coil domains 1.
      
 0.480
ATP6AP1L
V-type proton ATPase subunit S1-like protein; ATPase H+ transporting accessory protein 1 like.
   
  
 0.480
LRRC37A2
Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2.
    
 
 0.474
CUL7
Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...]
   
 
 0.465
STXBP4
Syntaxin-binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).
   
 
 0.453
LRRC37A
Leucine-rich repeat-containing protein 37A; Leucine rich repeat containing 37A.
    
 
 0.444
LRRC37A3
Leucine-rich repeat-containing protein 37A3; Leucine rich repeat containing 37 member A3.
    
 
 0.432
L3MBTL3
Lethal(3)malignant brain tumor-like protein 3; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).
   
 
 0.428
ANKLE1
Ankyrin repeat and LEM domain-containing protein 1; Endonuclease that probably plays a role in the DNA damage response and DNA repair.
    
 
 0.425
PLEKHD1
Pleckstrin homology and coiled-coil domain containing D1; Belongs to the PLEKHD1 family.
      
 0.413
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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