node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALKAL1 | FAM78A | ENSP00000351345 | ENSP00000361345 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly. | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | 0.447 |
ALKAL1 | RIMS4 | ENSP00000351345 | ENSP00000439287 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly. | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis. | 0.447 |
ALKAL1 | ZNF540 | ENSP00000351345 | ENSP00000324598 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly. | Zinc finger protein 540; May act as a transcriptional repressor. | 0.479 |
FAM78A | ALKAL1 | ENSP00000361345 | ENSP00000351345 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly. | 0.447 |
FAM78A | PCDHAC1 | ENSP00000361345 | ENSP00000253807 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. | 0.449 |
FAM78A | PRAC1 | ENSP00000361345 | ENSP00000290294 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | PRAC1 small nuclear protein. | 0.432 |
FAM78A | RIMS4 | ENSP00000361345 | ENSP00000439287 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis. | 0.480 |
FAM78A | ZNF540 | ENSP00000361345 | ENSP00000324598 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | Zinc finger protein 540; May act as a transcriptional repressor. | 0.572 |
KHDRBS2 | RIMS4 | ENSP00000281156 | ENSP00000439287 | KH domain-containing, RNA-binding, signal transduction-associated protein 2; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre- mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexi [...] | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis. | 0.408 |
KHDRBS2 | ZNF540 | ENSP00000281156 | ENSP00000324598 | KH domain-containing, RNA-binding, signal transduction-associated protein 2; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre- mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexi [...] | Zinc finger protein 540; May act as a transcriptional repressor. | 0.448 |
MVP | ZNF540 | ENSP00000378760 | ENSP00000324598 | Major vault protein; Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. | Zinc finger protein 540; May act as a transcriptional repressor. | 0.465 |
NRIP2 | ZNF540 | ENSP00000337501 | ENSP00000324598 | Nuclear receptor-interacting protein 2; Down-regulates transcriptional activation by nuclear receptors such as NR1F2. | Zinc finger protein 540; May act as a transcriptional repressor. | 0.432 |
PCDHAC1 | FAM78A | ENSP00000253807 | ENSP00000361345 | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | 0.449 |
PCDHAC1 | RIMS4 | ENSP00000253807 | ENSP00000439287 | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis. | 0.407 |
PCDHAC1 | ZNF540 | ENSP00000253807 | ENSP00000324598 | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. | Zinc finger protein 540; May act as a transcriptional repressor. | 0.475 |
PRAC1 | FAM78A | ENSP00000290294 | ENSP00000361345 | PRAC1 small nuclear protein. | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | 0.432 |
PRAC1 | ZNF540 | ENSP00000290294 | ENSP00000324598 | PRAC1 small nuclear protein. | Zinc finger protein 540; May act as a transcriptional repressor. | 0.449 |
RIMS4 | ALKAL1 | ENSP00000439287 | ENSP00000351345 | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis. | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly. | 0.447 |
RIMS4 | FAM78A | ENSP00000439287 | ENSP00000361345 | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis. | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family. | 0.480 |
RIMS4 | KHDRBS2 | ENSP00000439287 | ENSP00000281156 | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis. | KH domain-containing, RNA-binding, signal transduction-associated protein 2; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre- mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexi [...] | 0.408 |