node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BORCS6 | CPTP | ENSP00000373669 | ENSP00000343890 | BLOC-1-related complex subunit 6; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Belongs to the BORCS6 family. | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1- phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity [...] | 0.438 |
BORCS6 | ZNF524 | ENSP00000373669 | ENSP00000466907 | BLOC-1-related complex subunit 6; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Belongs to the BORCS6 family. | Zinc finger protein 524; May be involved in transcriptional regulation. | 0.677 |
CHD4 | ZNF524 | ENSP00000440542 | ENSP00000466907 | Chromodomain-helicase-DNA-binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Belongs to the SNF2/RAD54 helicase family. | Zinc finger protein 524; May be involved in transcriptional regulation. | 0.455 |
CPTP | BORCS6 | ENSP00000343890 | ENSP00000373669 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1- phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity [...] | BLOC-1-related complex subunit 6; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Belongs to the BORCS6 family. | 0.438 |
CPTP | ZNF524 | ENSP00000343890 | ENSP00000466907 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1- phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity [...] | Zinc finger protein 524; May be involved in transcriptional regulation. | 0.631 |
POLD1 | RPS6KL1 | ENSP00000472445 | ENSP00000450567 | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proo [...] | Ribosomal protein S6 kinase like 1. | 0.460 |
POLD1 | ZNF524 | ENSP00000472445 | ENSP00000466907 | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proo [...] | Zinc finger protein 524; May be involved in transcriptional regulation. | 0.535 |
RPS6KL1 | POLD1 | ENSP00000450567 | ENSP00000472445 | Ribosomal protein S6 kinase like 1. | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proo [...] | 0.460 |
RPS6KL1 | SNRPN | ENSP00000450567 | ENSP00000494831 | Ribosomal protein S6 kinase like 1. | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events. | 0.475 |
RPS6KL1 | ZNF524 | ENSP00000450567 | ENSP00000466907 | Ribosomal protein S6 kinase like 1. | Zinc finger protein 524; May be involved in transcriptional regulation. | 0.715 |
SNAPC2 | ZNF524 | ENSP00000221573 | ENSP00000466907 | snRNA-activating protein complex subunit 2; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. | Zinc finger protein 524; May be involved in transcriptional regulation. | 0.461 |
SNRPN | RPS6KL1 | ENSP00000494831 | ENSP00000450567 | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events. | Ribosomal protein S6 kinase like 1. | 0.475 |
SNRPN | ZNF524 | ENSP00000494831 | ENSP00000466907 | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events. | Zinc finger protein 524; May be involved in transcriptional regulation. | 0.533 |
THG1L | ZNF524 | ENSP00000231198 | ENSP00000466907 | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. | Zinc finger protein 524; May be involved in transcriptional regulation. | 0.556 |
VRK3 | ZNF524 | ENSP00000469880 | ENSP00000466907 | Inactive serine/threonine-protein kinase VRK3; Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. | Zinc finger protein 524; May be involved in transcriptional regulation. | 0.476 |
YY1AP1 | ZNF524 | ENSP00000357323 | ENSP00000466907 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation. | Zinc finger protein 524; May be involved in transcriptional regulation. | 0.451 |
ZNF524 | BORCS6 | ENSP00000466907 | ENSP00000373669 | Zinc finger protein 524; May be involved in transcriptional regulation. | BLOC-1-related complex subunit 6; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Belongs to the BORCS6 family. | 0.677 |
ZNF524 | CHD4 | ENSP00000466907 | ENSP00000440542 | Zinc finger protein 524; May be involved in transcriptional regulation. | Chromodomain-helicase-DNA-binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Belongs to the SNF2/RAD54 helicase family. | 0.455 |
ZNF524 | CPTP | ENSP00000466907 | ENSP00000343890 | Zinc finger protein 524; May be involved in transcriptional regulation. | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1- phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity [...] | 0.631 |
ZNF524 | POLD1 | ENSP00000466907 | ENSP00000472445 | Zinc finger protein 524; May be involved in transcriptional regulation. | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proo [...] | 0.535 |