STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM101Transmembrane protein 101; May activate NF-kappa-B signaling pathways. (257 aa)    
Predicted Functional Partners:
TMEM223
Transmembrane protein 223.
   
  
 0.624
TMEM115
Transmembrane protein 115; May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.
   
  
 0.525
TMEM208
Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
   
  
 0.523
TMEM120A
Transmembrane protein 120A; Necessary for efficient adipogenesis. Belongs to the TMEM120 family.
   
  
 0.518
RPP40
Ribonuclease P protein subunit p40; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
   
  
 0.510
TMEM59L
Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.
      
 0.486
FAM181B
Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family.
      
 0.477
LSM12
LSM12 homolog.
 
 
  
 0.457
RPP25L
Ribonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP.
   
    0.450
LAGE3
EKC/KEOPS complex subunit LAGE3; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex; Belongs to the CTAG/PCC1 family.
   
  
 0.449
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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