node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP13A1 | GMIP | ENSP00000349877 | ENSP00000203556 | Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA. | 0.434 |
ATP13A1 | YJEFN3 | ENSP00000349877 | ENSP00000426964 | Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | YjeF N-terminal domain-containing protein 3; May play a role in spermiogenesis and oogenesis. | 0.495 |
ATP13A1 | ZNF101 | ENSP00000349877 | ENSP00000468049 | Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Zinc finger protein 101; May be involved in transcriptional regulation. | 0.451 |
C5orf58 | TSSK6 | ENSP00000490013 | ENSP00000466477 | Putative uncharacterized protein C5orf58; Chromosome 5 open reading frame 58. | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). | 0.447 |
C5orf58 | ZNF101 | ENSP00000490013 | ENSP00000468049 | Putative uncharacterized protein C5orf58; Chromosome 5 open reading frame 58. | Zinc finger protein 101; May be involved in transcriptional regulation. | 0.433 |
GMIP | ATP13A1 | ENSP00000203556 | ENSP00000349877 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA. | Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.434 |
GMIP | YJEFN3 | ENSP00000203556 | ENSP00000426964 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA. | YjeF N-terminal domain-containing protein 3; May play a role in spermiogenesis and oogenesis. | 0.481 |
GMIP | ZNF101 | ENSP00000203556 | ENSP00000468049 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA. | Zinc finger protein 101; May be involved in transcriptional regulation. | 0.448 |
HINFP | TAF8 | ENSP00000318085 | ENSP00000362068 | Histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. | Transcription initiation factor TFIID subunit 8; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). Be [...] | 0.780 |
HINFP | ZNF101 | ENSP00000318085 | ENSP00000468049 | Histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. | Zinc finger protein 101; May be involved in transcriptional regulation. | 0.456 |
HINFP | ZNF766 | ENSP00000318085 | ENSP00000409652 | Histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. | Zinc finger protein 766; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.727 |
TAF8 | HINFP | ENSP00000362068 | ENSP00000318085 | Transcription initiation factor TFIID subunit 8; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). Be [...] | Histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. | 0.780 |
TAF8 | ZNF101 | ENSP00000362068 | ENSP00000468049 | Transcription initiation factor TFIID subunit 8; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). Be [...] | Zinc finger protein 101; May be involved in transcriptional regulation. | 0.472 |
TRIM28 | ZNF101 | ENSP00000253024 | ENSP00000468049 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 101; May be involved in transcriptional regulation. | 0.606 |
TRIM28 | ZNF431 | ENSP00000253024 | ENSP00000308578 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 431; Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.522 |
TRIM28 | ZNF766 | ENSP00000253024 | ENSP00000409652 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 766; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.555 |
TSSK6 | C5orf58 | ENSP00000466477 | ENSP00000490013 | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). | Putative uncharacterized protein C5orf58; Chromosome 5 open reading frame 58. | 0.447 |
TSSK6 | YJEFN3 | ENSP00000466477 | ENSP00000426964 | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). | YjeF N-terminal domain-containing protein 3; May play a role in spermiogenesis and oogenesis. | 0.546 |
TSSK6 | ZNF101 | ENSP00000466477 | ENSP00000468049 | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity). | Zinc finger protein 101; May be involved in transcriptional regulation. | 0.434 |
YJEFN3 | ATP13A1 | ENSP00000426964 | ENSP00000349877 | YjeF N-terminal domain-containing protein 3; May play a role in spermiogenesis and oogenesis. | Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.495 |