node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPL | SEC11C | ENSP00000363973 | ENSP00000468633 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Signal peptidase complex catalytic subunit SEC11C; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.796 |
ALPL | SPCS2 | ENSP00000363973 | ENSP00000263672 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family. | Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.787 |
POLR2G | SEC11A | ENSP00000301788 | ENSP00000452697 | DNA-directed RNA polymerase II subunit RPB7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems [...] | SEC11 homolog A, signal peptidase complex subunit. | 0.850 |
POLR2G | SEC11C | ENSP00000301788 | ENSP00000468633 | DNA-directed RNA polymerase II subunit RPB7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems [...] | Signal peptidase complex catalytic subunit SEC11C; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.770 |
RPL26 | SEC11A | ENSP00000463784 | ENSP00000452697 | 60S ribosomal protein L26; Component of the large ribosomal subunit. | SEC11 homolog A, signal peptidase complex subunit. | 0.677 |
RPL26 | SEC11C | ENSP00000463784 | ENSP00000468633 | 60S ribosomal protein L26; Component of the large ribosomal subunit. | Signal peptidase complex catalytic subunit SEC11C; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.713 |
RPL26 | SEC61A1 | ENSP00000463784 | ENSP00000243253 | 60S ribosomal protein L26; Component of the large ribosomal subunit. | Protein transport protein Sec61 subunit alpha isoform 1; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC6 [...] | 0.986 |
RPL26 | SEC61B | ENSP00000463784 | ENSP00000223641 | 60S ribosomal protein L26; Component of the large ribosomal subunit. | Protein transport protein Sec61 subunit beta; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis (By similarity). | 0.957 |
RPL26 | SEC61G | ENSP00000463784 | ENSP00000388337 | 60S ribosomal protein L26; Component of the large ribosomal subunit. | Protein transport protein Sec61 subunit gamma; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER); Belongs to the SecE/SEC61-gamma family. | 0.971 |
RPL26 | SPCS1 | ENSP00000463784 | ENSP00000233025 | 60S ribosomal protein L26; Component of the large ribosomal subunit. | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the SPCS1 family. | 0.496 |
RPL26 | SPCS2 | ENSP00000463784 | ENSP00000263672 | 60S ribosomal protein L26; Component of the large ribosomal subunit. | Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.722 |
RPL26 | SPCS3 | ENSP00000463784 | ENSP00000427463 | 60S ribosomal protein L26; Component of the large ribosomal subunit. | Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum; Belongs to the SPCS3 family. | 0.405 |
SEC11A | POLR2G | ENSP00000452697 | ENSP00000301788 | SEC11 homolog A, signal peptidase complex subunit. | DNA-directed RNA polymerase II subunit RPB7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems [...] | 0.850 |
SEC11A | RPL26 | ENSP00000452697 | ENSP00000463784 | SEC11 homolog A, signal peptidase complex subunit. | 60S ribosomal protein L26; Component of the large ribosomal subunit. | 0.677 |
SEC11A | SEC11C | ENSP00000452697 | ENSP00000468633 | SEC11 homolog A, signal peptidase complex subunit. | Signal peptidase complex catalytic subunit SEC11C; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.946 |
SEC11A | SEC61A1 | ENSP00000452697 | ENSP00000243253 | SEC11 homolog A, signal peptidase complex subunit. | Protein transport protein Sec61 subunit alpha isoform 1; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC6 [...] | 0.743 |
SEC11A | SEC61B | ENSP00000452697 | ENSP00000223641 | SEC11 homolog A, signal peptidase complex subunit. | Protein transport protein Sec61 subunit beta; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis (By similarity). | 0.633 |
SEC11A | SEC61G | ENSP00000452697 | ENSP00000388337 | SEC11 homolog A, signal peptidase complex subunit. | Protein transport protein Sec61 subunit gamma; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER); Belongs to the SecE/SEC61-gamma family. | 0.731 |
SEC11A | SPCS1 | ENSP00000452697 | ENSP00000233025 | SEC11 homolog A, signal peptidase complex subunit. | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the SPCS1 family. | 0.995 |
SEC11A | SPCS2 | ENSP00000452697 | ENSP00000263672 | SEC11 homolog A, signal peptidase complex subunit. | Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. | 0.997 |