| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C6orf15 | M0QX08_HUMAN | ENSP00000259870 | ENSP00000468837 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15. | Protein kinase domain-containing protein. | 0.422 |
| CHEK2 | M0QX08_HUMAN | ENSP00000372023 | ENSP00000468837 | Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...] | Protein kinase domain-containing protein. | 0.504 |
| M0QX08_HUMAN | C6orf15 | ENSP00000468837 | ENSP00000259870 | Protein kinase domain-containing protein. | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15. | 0.422 |
| M0QX08_HUMAN | CHEK2 | ENSP00000468837 | ENSP00000372023 | Protein kinase domain-containing protein. | Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...] | 0.504 |
| M0QX08_HUMAN | POLR3H | ENSP00000468837 | ENSP00000347345 | Protein kinase domain-containing protein. | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | 0.473 |
| M0QX08_HUMAN | SUPT5H | ENSP00000468837 | ENSP00000470252 | Protein kinase domain-containing protein. | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote paus [...] | 0.422 |
| POLR3H | M0QX08_HUMAN | ENSP00000347345 | ENSP00000468837 | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | Protein kinase domain-containing protein. | 0.473 |
| SUPT5H | M0QX08_HUMAN | ENSP00000470252 | ENSP00000468837 | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote paus [...] | Protein kinase domain-containing protein. | 0.422 |
