node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
METTL22 | SLC25A53 | ENSP00000371345 | ENSP00000468980 | Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN. Belongs to the methyltransferase superfamily. METTL22 family. | Solute carrier family 25 member 53. | 0.545 |
SLC25A1 | SLC25A53 | ENSP00000215882 | ENSP00000468980 | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable). | Solute carrier family 25 member 53. | 0.489 |
SLC25A17 | SLC25A53 | ENSP00000390722 | ENSP00000468980 | Peroxisomal membrane protein PMP34; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'- phosphate and bathophenanthroline in vitro. Belongs to the mitochondrial carrie [...] | Solute carrier family 25 member 53. | 0.529 |
SLC25A30 | SLC25A53 | ENSP00000429168 | ENSP00000468980 | Kidney mitochondrial carrier protein 1; Probable transporter; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Solute carrier family 25 member 53. | 0.491 |
SLC25A32 | SLC25A53 | ENSP00000297578 | ENSP00000468980 | Mitochondrial folate transporter/carrier; Transports folate across the inner membranes of mitochondria. Can also transport FAD across the mitochondrial inner membrane. | Solute carrier family 25 member 53. | 0.604 |
SLC25A33 | SLC25A53 | ENSP00000306328 | ENSP00000468980 | Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and m [...] | Solute carrier family 25 member 53. | 0.540 |
SLC25A34 | SLC25A53 | ENSP00000294454 | ENSP00000468980 | Solute carrier family 25 member 34. | Solute carrier family 25 member 53. | 0.490 |
SLC25A35 | SLC25A53 | ENSP00000464231 | ENSP00000468980 | Solute carrier family 25 member 35; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Solute carrier family 25 member 53. | 0.613 |
SLC25A36 | SLC25A53 | ENSP00000320688 | ENSP00000468980 | Solute carrier family 25 member 36; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potentia [...] | Solute carrier family 25 member 53. | 0.567 |
SLC25A43 | SLC25A53 | ENSP00000217909 | ENSP00000468980 | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Solute carrier family 25 member 53. | 0.677 |
SLC25A53 | METTL22 | ENSP00000468980 | ENSP00000371345 | Solute carrier family 25 member 53. | Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN. Belongs to the methyltransferase superfamily. METTL22 family. | 0.545 |
SLC25A53 | SLC25A1 | ENSP00000468980 | ENSP00000215882 | Solute carrier family 25 member 53. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable). | 0.489 |
SLC25A53 | SLC25A17 | ENSP00000468980 | ENSP00000390722 | Solute carrier family 25 member 53. | Peroxisomal membrane protein PMP34; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'- phosphate and bathophenanthroline in vitro. Belongs to the mitochondrial carrie [...] | 0.529 |
SLC25A53 | SLC25A30 | ENSP00000468980 | ENSP00000429168 | Solute carrier family 25 member 53. | Kidney mitochondrial carrier protein 1; Probable transporter; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.491 |
SLC25A53 | SLC25A32 | ENSP00000468980 | ENSP00000297578 | Solute carrier family 25 member 53. | Mitochondrial folate transporter/carrier; Transports folate across the inner membranes of mitochondria. Can also transport FAD across the mitochondrial inner membrane. | 0.604 |
SLC25A53 | SLC25A33 | ENSP00000468980 | ENSP00000306328 | Solute carrier family 25 member 53. | Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and m [...] | 0.540 |
SLC25A53 | SLC25A34 | ENSP00000468980 | ENSP00000294454 | Solute carrier family 25 member 53. | Solute carrier family 25 member 34. | 0.490 |
SLC25A53 | SLC25A35 | ENSP00000468980 | ENSP00000464231 | Solute carrier family 25 member 53. | Solute carrier family 25 member 35; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.613 |
SLC25A53 | SLC25A36 | ENSP00000468980 | ENSP00000320688 | Solute carrier family 25 member 53. | Solute carrier family 25 member 36; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potentia [...] | 0.567 |
SLC25A53 | SLC25A43 | ENSP00000468980 | ENSP00000217909 | Solute carrier family 25 member 53. | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.677 |