STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF628Zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3' (By similarity). (1059 aa)    
Predicted Functional Partners:
UBALD1
UBA-like domain-containing protein 1; UBA like domain containing 1.
   
  
 0.641
ZNF341
Zinc finger protein 341; Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription. Belongs to the krueppel C2H2-type zinc-finger protein family.
   
   
0.618
TCEAL4
Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation.
    
 
 0.583
KIAA0408
Uncharacterized protein KIAA0408; KIAA0408.
      
 0.575
FGD1
FYVE, RhoGEF and PH domain-containing protein 1; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
   
  
 0.493
INAFM1
Putative transmembrane protein INAFM1; InaF motif containing 1.
   
  
 0.486
MIS18BP1
Mis18-binding protein 1; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
      
 0.482
CAMTA2
Calmodulin-binding transcription activator 2; Transcription activator. May act as tumor suppressor. Belongs to the CAMTA family.
   
 
 0.472
CCDC80
Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly.
    
 
 0.456
EFEMP1
EGF-containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth; Belongs to the fibulin family.
    
   0.453
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.