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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF225Ring finger protein 225. (329 aa)    
Predicted Functional Partners:
ZNF584
Zinc finger protein 584; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
   
 
 0.658
GASK1A
Golgi associated kinase 1A; Belongs to the GASK family.
      
 0.606
OR4D6
Olfactory receptor 4D6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.583
ALG10B
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N- linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2. Has a role in maintenance of cochlear outer hair cell function (By similarity).
   
  
 0.510
SPANXD
Sperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family.
    
 
 0.478
ENSP00000466140
Novel protein.
      
 0.477
CGB1
Chorionic gonadotropin subunit beta 1.
      
 0.474
PIR
Pirin; Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox- state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). Belongs to the pirin family.
      
 0.429
ZNF341
Zinc finger protein 341; Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription. Belongs to the krueppel C2H2-type zinc-finger protein family.
   
 
 0.424
ANKRD30A
Ankyrin repeat domain 30A.
    
 
 0.415
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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