node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APEH | FAM234A | ENSP00000296456 | ENSP00000382814 | Acylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser; Belongs to the peptidase S9C family. | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | 0.464 |
APEH | L3HYPDH | ENSP00000296456 | ENSP00000247194 | Acylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser; Belongs to the peptidase S9C family. | Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. | 0.421 |
FAM234A | APEH | ENSP00000382814 | ENSP00000296456 | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | Acylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser; Belongs to the peptidase S9C family. | 0.464 |
FAM234A | FGD4 | ENSP00000382814 | ENSP00000433666 | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | FYVE, RhoGEF and PH domain-containing protein 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). | 0.438 |
FAM234A | HBA1 | ENSP00000382814 | ENSP00000322421 | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | Hemoglobin subunit alpha 1. | 0.418 |
FAM234A | HBQ1 | ENSP00000382814 | ENSP00000199708 | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | Hemoglobin subunit theta 1. | 0.432 |
FAM234A | KCTD18 | ENSP00000382814 | ENSP00000352941 | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | 0.438 |
FAM234A | L3HYPDH | ENSP00000382814 | ENSP00000247194 | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. | 0.454 |
FAM234A | LUC7L | ENSP00000382814 | ENSP00000293872 | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | 0.451 |
FAM234A | RGS11 | ENSP00000382814 | ENSP00000380876 | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | Regulator of G-protein signaling 11; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. | 0.411 |
FAM234A | RNF122 | ENSP00000382814 | ENSP00000256257 | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability. | 0.464 |
FAM234A | SLC4A5 | ENSP00000382814 | ENSP00000251768 | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | Electrogenic sodium bicarbonate cotransporter 4; Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH; Belongs to the anion exchanger (TC 2.A.31) family. | 0.450 |
FGD4 | FAM234A | ENSP00000433666 | ENSP00000382814 | FYVE, RhoGEF and PH domain-containing protein 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | 0.438 |
HBA1 | FAM234A | ENSP00000322421 | ENSP00000382814 | Hemoglobin subunit alpha 1. | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | 0.418 |
HBA1 | HBQ1 | ENSP00000322421 | ENSP00000199708 | Hemoglobin subunit alpha 1. | Hemoglobin subunit theta 1. | 0.666 |
HBA1 | LUC7L | ENSP00000322421 | ENSP00000293872 | Hemoglobin subunit alpha 1. | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | 0.740 |
HBQ1 | FAM234A | ENSP00000199708 | ENSP00000382814 | Hemoglobin subunit theta 1. | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | 0.432 |
HBQ1 | HBA1 | ENSP00000199708 | ENSP00000322421 | Hemoglobin subunit theta 1. | Hemoglobin subunit alpha 1. | 0.666 |
HBQ1 | LUC7L | ENSP00000199708 | ENSP00000293872 | Hemoglobin subunit theta 1. | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | 0.855 |
KCTD18 | FAM234A | ENSP00000352941 | ENSP00000382814 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18. | Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family. | 0.438 |