node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTAG1B | GAGE1 | ENSP00000332602 | ENSP00000484668 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | 0.620 |
CTAG1B | HSPA4 | ENSP00000332602 | ENSP00000302961 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | 0.529 |
CTAG1B | MAGED4 | ENSP00000332602 | ENSP00000472118 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | MAGE family member D4. | 0.695 |
CTAG1B | MAGED4B | ENSP00000332602 | ENSP00000421861 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. | 0.698 |
CTAG1B | PMEL | ENSP00000332602 | ENSP00000402758 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. | 0.857 |
CTAG1B | PRAME | ENSP00000332602 | ENSP00000445675 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. | 0.752 |
CTAG1B | SSX2 | ENSP00000332602 | ENSP00000338796 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | SSX family member 2. | 0.814 |
CTAG1B | TYR | ENSP00000332602 | ENSP00000263321 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family. | 0.861 |
GAGE1 | CTAG1B | ENSP00000484668 | ENSP00000332602 | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | 0.620 |
GAGE1 | MAGED4 | ENSP00000484668 | ENSP00000472118 | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | MAGE family member D4. | 0.667 |
GAGE1 | MAGED4B | ENSP00000484668 | ENSP00000421861 | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. | 0.666 |
GAGE1 | PRAME | ENSP00000484668 | ENSP00000445675 | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. | 0.487 |
GAGE1 | SSX2 | ENSP00000484668 | ENSP00000338796 | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | SSX family member 2. | 0.617 |
HSPA4 | CTAG1B | ENSP00000302961 | ENSP00000332602 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | 0.529 |
HSPA4 | MAGED4 | ENSP00000302961 | ENSP00000472118 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | MAGE family member D4. | 0.888 |
HSPA4 | MAGED4B | ENSP00000302961 | ENSP00000421861 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. | 0.888 |
HSPA4 | PMEL | ENSP00000302961 | ENSP00000402758 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. | Melanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. | 0.556 |
IL13RA2 | MAGED4 | ENSP00000361004 | ENSP00000472118 | Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). | MAGE family member D4. | 0.678 |
IL13RA2 | MAGED4B | ENSP00000361004 | ENSP00000421861 | Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). | Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. | 0.678 |
IL13RA2 | PMEL | ENSP00000361004 | ENSP00000402758 | Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). | Melanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. | 0.678 |