node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSL5 | ASCL5 | ENSP00000348429 | ENSP00000472681 | Long-chain-fatty-acid--CoA ligase 5; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small [...] | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | 0.543 |
ASCL5 | ACSL5 | ENSP00000472681 | ENSP00000348429 | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | Long-chain-fatty-acid--CoA ligase 5; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small [...] | 0.543 |
ASCL5 | BHLHA9 | ENSP00000472681 | ENSP00000375248 | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis. | 0.532 |
ASCL5 | BHLHE23 | ENSP00000472681 | ENSP00000480998 | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | Class E basic helix-loop-helix protein 23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity). | 0.562 |
ASCL5 | GPR25 | ENSP00000472681 | ENSP00000301917 | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | Probable G-protein coupled receptor 25; Orphan receptor. | 0.431 |
ASCL5 | PPP1R3G | ENSP00000472681 | ENSP00000393832 | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | Protein phosphatase 1 regulatory subunit 3G; Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity). | 0.447 |
ASCL5 | TMEM170B | ENSP00000472681 | ENSP00000368737 | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family. | 0.483 |
ASCL5 | ZNF316 | ENSP00000472681 | ENSP00000477706 | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | Zinc finger protein 316; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.400 |
BHLHA9 | ASCL5 | ENSP00000375248 | ENSP00000472681 | Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis. | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | 0.532 |
BHLHA9 | BHLHE23 | ENSP00000375248 | ENSP00000480998 | Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis. | Class E basic helix-loop-helix protein 23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity). | 0.470 |
BHLHE23 | ASCL5 | ENSP00000480998 | ENSP00000472681 | Class E basic helix-loop-helix protein 23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity). | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | 0.562 |
BHLHE23 | BHLHA9 | ENSP00000480998 | ENSP00000375248 | Class E basic helix-loop-helix protein 23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity). | Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis. | 0.470 |
GPR25 | ASCL5 | ENSP00000301917 | ENSP00000472681 | Probable G-protein coupled receptor 25; Orphan receptor. | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | 0.431 |
PPP1R3G | ASCL5 | ENSP00000393832 | ENSP00000472681 | Protein phosphatase 1 regulatory subunit 3G; Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity). | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | 0.447 |
TMEM170B | ASCL5 | ENSP00000368737 | ENSP00000472681 | Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets. Belongs to the TMEM170 family. | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | 0.483 |
ZNF316 | ASCL5 | ENSP00000477706 | ENSP00000472681 | Zinc finger protein 316; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5. | 0.400 |