node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSAG1 | GAGE2A | ENSP00000359310 | ENSP00000355421 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | G antigen 2A. | 0.453 |
CSAG1 | MAGEA12 | ENSP00000359310 | ENSP00000377447 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. | 0.999 |
CSAG1 | MAGEA3 | ENSP00000359310 | ENSP00000473093 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.980 |
CSAG1 | MAGEA6 | ENSP00000359310 | ENSP00000480637 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | Melanoma-associated antigen 6; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. | 0.925 |
CTAG1B | CTAG2 | ENSP00000332602 | ENSP00000247306 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | 0.868 |
CTAG1B | GAGE1 | ENSP00000332602 | ENSP00000484668 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | 0.620 |
CTAG1B | GAGE12F | ENSP00000332602 | ENSP00000491865 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | G antigen 12F. | 0.564 |
CTAG1B | MAGEA12 | ENSP00000332602 | ENSP00000377447 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. | 0.767 |
CTAG1B | MAGEA3 | ENSP00000332602 | ENSP00000473093 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.974 |
CTAG1B | MAGEA6 | ENSP00000332602 | ENSP00000480637 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 6; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. | 0.864 |
CTAG1B | TYR | ENSP00000332602 | ENSP00000263321 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family. | 0.861 |
CTAG2 | CTAG1B | ENSP00000247306 | ENSP00000332602 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | 0.868 |
CTAG2 | GAGE1 | ENSP00000247306 | ENSP00000484668 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | 0.686 |
CTAG2 | GAGE12F | ENSP00000247306 | ENSP00000491865 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | G antigen 12F. | 0.428 |
CTAG2 | GAGE2A | ENSP00000247306 | ENSP00000355421 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | G antigen 2A. | 0.538 |
CTAG2 | MAGEA12 | ENSP00000247306 | ENSP00000377447 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. | 0.692 |
CTAG2 | MAGEA3 | ENSP00000247306 | ENSP00000473093 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.897 |
CTAG2 | MAGEA6 | ENSP00000247306 | ENSP00000480637 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 6; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. | 0.878 |
GAGE1 | CTAG1B | ENSP00000484668 | ENSP00000332602 | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | 0.620 |
GAGE1 | CTAG2 | ENSP00000484668 | ENSP00000247306 | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | 0.686 |