STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRIM77Tripartite motif containing 77; Belongs to the TRIM/RBCC family. (450 aa)    
Predicted Functional Partners:
TRIM42
Tripartite motif containing 42; Belongs to the TRIM/RBCC family.
   
  
 0.543
ZNF396
Zinc finger protein 396; Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors.
   
 
 0.492
FAM153A
Protein FAM153A; Family with sequence similarity 153 member A; Belongs to the FAM153 family.
      
 0.480
TRIM52
E3 ubiquitin-protein ligase TRIM52; E3 ubiquitin-protein ligase. Positively regulates the NF-kappa-B signaling pathway.
      
 0.420
TRIM55
Tripartite motif-containing protein 55; May regulate gene expression and protein turnover in muscle cells.
      
 0.418
H1-8
Histone H1oo; May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling ( [...]
  
  
 0.410
TRIM59
Tripartite motif-containing protein 59; May serve as a multifunctional regulator for innate immune signaling pathways.
      
 0.404
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.