STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
H2AC19H2A clustered histone 19. (130 aa)    
Predicted Functional Partners:
H3C15
H3 clustered histone 15.
 
 
 
 0.963
H4C14
H4 clustered histone 14.
 
 
 
 0.963
H2BC12
Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 
 
 
 0.962
H4C15
H4 clustered histone 15.
 
 
 
 0.961
H3C14
H3 clustered histone 14.
 
 
 
 0.960
H4C2
H4 clustered histone 2.
 
 
 
 0.959
H4C12
H4 clustered histone 12.
 
 
 
 0.958
H4C11
H4 clustered histone 11.
 
 
 
 0.957
H4C4
H4 clustered histone 4.
 
 
 
 0.957
H4C8
H4 clustered histone 8.
 
 
 
 0.957
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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