node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD274 | PDCD1 | ENSP00000370989 | ENSP00000335062 | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | Programmed cell death protein 1; Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the pr [...] | 0.999 |
CD274 | SLC25A16 | ENSP00000370989 | ENSP00000476815 | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.576 |
CS | MTCH1 | ENSP00000342056 | ENSP00000362730 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | 0.431 |
CS | SLC25A16 | ENSP00000342056 | ENSP00000476815 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.819 |
CS | TRIM13 | ENSP00000342056 | ENSP00000348299 | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | E3 ubiquitin-protein ligase TRIM13; Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER- associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress- induced autophagy, and [...] | 0.644 |
FAU | RPL18 | ENSP00000431822 | ENSP00000447001 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 60S ribosomal protein L18; Component of the large ribosomal subunit. | 0.999 |
FAU | SLC25A16 | ENSP00000431822 | ENSP00000476815 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.821 |
MTCH1 | CS | ENSP00000362730 | ENSP00000342056 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | 0.431 |
MTCH1 | SLC25A16 | ENSP00000362730 | ENSP00000476815 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.781 |
MTCH2 | SLC25A16 | ENSP00000303222 | ENSP00000476815 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.786 |
PAEP | SLC25A16 | ENSP00000417898 | ENSP00000476815 | Glycodelin; Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the u [...] | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.576 |
PDCD1 | CD274 | ENSP00000335062 | ENSP00000370989 | Programmed cell death protein 1; Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the pr [...] | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | 0.999 |
PDCD1 | SLC25A16 | ENSP00000335062 | ENSP00000476815 | Programmed cell death protein 1; Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the pr [...] | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.574 |
RPL18 | FAU | ENSP00000447001 | ENSP00000431822 | 60S ribosomal protein L18; Component of the large ribosomal subunit. | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 0.999 |
RPL18 | SLC25A16 | ENSP00000447001 | ENSP00000476815 | 60S ribosomal protein L18; Component of the large ribosomal subunit. | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.909 |
SLC25A16 | CD274 | ENSP00000476815 | ENSP00000370989 | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). | 0.576 |
SLC25A16 | CS | ENSP00000476815 | ENSP00000342056 | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. | 0.819 |
SLC25A16 | FAU | ENSP00000476815 | ENSP00000431822 | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 0.821 |
SLC25A16 | MTCH1 | ENSP00000476815 | ENSP00000362730 | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis. | 0.781 |
SLC25A16 | MTCH2 | ENSP00000476815 | ENSP00000303222 | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.786 |