| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C15orf48 | SMIM5 | ENSP00000341610 | ENSP00000477017 | Normal mucosa of esophagus-specific gene 1 protein; Chromosome 15 open reading frame 48; Belongs to the complex I NDUFA4 subunit family. | Small integral membrane protein 5. | 0.463 |
| CYSRT1 | SMIM5 | ENSP00000386453 | ENSP00000477017 | Cysteine rich tail 1. | Small integral membrane protein 5. | 0.482 |
| DNAH6 | SMIM5 | ENSP00000374045 | ENSP00000477017 | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | Small integral membrane protein 5. | 0.465 |
| GDPD3 | SMIM5 | ENSP00000384363 | ENSP00000477017 | Lysophospholipase D GDPD3; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) and lysophosphatidylcholine (lyso-PC), and to a lesser extent for lysophosphatidylethanolamine (lyso-PE). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. | Small integral membrane protein 5. | 0.455 |
| PRR15L | SMIM5 | ENSP00000300557 | ENSP00000477017 | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family. | Small integral membrane protein 5. | 0.411 |
| RECQL5 | SMIM5 | ENSP00000317636 | ENSP00000477017 | ATP-dependent DNA helicase Q5; Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. | Small integral membrane protein 5. | 0.413 |
| RET | SMIM5 | ENSP00000347942 | ENSP00000477017 | Extracellular cell-membrane anchored RET cadherin 120 kDa fragment; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and [...] | Small integral membrane protein 5. | 0.542 |
| RIIAD1 | SMIM5 | ENSP00000419249 | ENSP00000477017 | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | Small integral membrane protein 5. | 0.422 |
| SGTA | SMIM5 | ENSP00000221566 | ENSP00000477017 | Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Co-chaperone that binds misfolded and hydrophobic patches- containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail- anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved i [...] | Small integral membrane protein 5. | 0.798 |
| SLC26A9 | SMIM5 | ENSP00000356102 | ENSP00000477017 | Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | Small integral membrane protein 5. | 0.451 |
| SMIM5 | C15orf48 | ENSP00000477017 | ENSP00000341610 | Small integral membrane protein 5. | Normal mucosa of esophagus-specific gene 1 protein; Chromosome 15 open reading frame 48; Belongs to the complex I NDUFA4 subunit family. | 0.463 |
| SMIM5 | CYSRT1 | ENSP00000477017 | ENSP00000386453 | Small integral membrane protein 5. | Cysteine rich tail 1. | 0.482 |
| SMIM5 | DNAH6 | ENSP00000477017 | ENSP00000374045 | Small integral membrane protein 5. | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity); Belongs to the dynein heavy chain family. | 0.465 |
| SMIM5 | GDPD3 | ENSP00000477017 | ENSP00000384363 | Small integral membrane protein 5. | Lysophospholipase D GDPD3; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) and lysophosphatidylcholine (lyso-PC), and to a lesser extent for lysophosphatidylethanolamine (lyso-PE). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. | 0.455 |
| SMIM5 | PRR15L | ENSP00000477017 | ENSP00000300557 | Small integral membrane protein 5. | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family. | 0.411 |
| SMIM5 | RECQL5 | ENSP00000477017 | ENSP00000317636 | Small integral membrane protein 5. | ATP-dependent DNA helicase Q5; Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. | 0.413 |
| SMIM5 | RET | ENSP00000477017 | ENSP00000347942 | Small integral membrane protein 5. | Extracellular cell-membrane anchored RET cadherin 120 kDa fragment; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and [...] | 0.542 |
| SMIM5 | RIIAD1 | ENSP00000477017 | ENSP00000419249 | Small integral membrane protein 5. | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | 0.422 |
| SMIM5 | SGTA | ENSP00000477017 | ENSP00000221566 | Small integral membrane protein 5. | Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Co-chaperone that binds misfolded and hydrophobic patches- containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail- anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved i [...] | 0.798 |
| SMIM5 | SLC26A9 | ENSP00000477017 | ENSP00000356102 | Small integral membrane protein 5. | Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.451 |
