Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
ZNF595Zinc finger protein 595; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (648 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]
    
 0.896
ZNF519
Zinc finger protein 519; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
   
0.855
ZNF732
Zinc finger protein 732; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
  
0.849
ZNF141
Zinc finger protein 141; May be involved in transcriptional regulation as a repressor. Plays a role in limb development; Belongs to the krueppel C2H2-type zinc-finger protein family.
  
  
0.739
ZNF718
Zinc finger protein 718; May be involved in transcriptional regulation.
  
  
0.739
ANKRD20A2
Ankyrin repeat domain-containing protein 20A2.
      
 0.570
THSD7B
Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B.
      
 0.553
OR5L1
Olfactory receptor 5L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.480
HNRNPL
Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.
   
   0.467
NIPA2
Magnesium transporter NIPA2; Acts as a selective Mg(2+) transporter; Belongs to the NIPA family.
      
 0.448
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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