TPT1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEF1A1	RPL18A	ENSP00000339063	ENSP00000222247	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.	0.999
EEF1A1	RPL19	ENSP00000339063	ENSP00000225430	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	0.998
EEF1A1	RPL4	ENSP00000339063	ENSP00000311430	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Ribosomal protein L4.	0.996
EEF1A1	RPLP2	ENSP00000339063	ENSP00000431240	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis.	0.992
EEF1A1	RPS16	ENSP00000339063	ENSP00000367806	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Ribosomal protein S16.	0.996
EEF1A1	RPS3A	ENSP00000339063	ENSP00000346050	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family.	0.999
EEF1A1	RPS8	ENSP00000339063	ENSP00000379888	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.	0.999
EEF1A1	TPT1	ENSP00000339063	ENSP00000477781	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization.	0.999
NHSL2	PICK1	ENSP00000488668	ENSP00000385205	NHS-like protein 2; NHS like 2; Belongs to the NHS family.	PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...]	0.999
NHSL2	TPT1	ENSP00000488668	ENSP00000477781	NHS-like protein 2; NHS like 2; Belongs to the NHS family.	Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization.	0.999
PICK1	NHSL2	ENSP00000385205	ENSP00000488668	PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...]	NHS-like protein 2; NHS like 2; Belongs to the NHS family.	0.999
PICK1	TPT1	ENSP00000385205	ENSP00000477781	PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...]	Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization.	0.999
RPL18A	EEF1A1	ENSP00000222247	ENSP00000339063	Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	0.999
RPL18A	RPL19	ENSP00000222247	ENSP00000225430	Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.	Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.	0.999
RPL18A	RPL4	ENSP00000222247	ENSP00000311430	Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.	Ribosomal protein L4.	0.999
RPL18A	RPLP2	ENSP00000222247	ENSP00000431240	Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.	60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis.	0.999
RPL18A	RPS16	ENSP00000222247	ENSP00000367806	Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.	Ribosomal protein S16.	0.999
RPL18A	RPS3A	ENSP00000222247	ENSP00000346050	Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.	40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family.	0.999
RPL18A	RPS8	ENSP00000222247	ENSP00000379888	Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.	Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.	0.999
RPL18A	TPT1	ENSP00000222247	ENSP00000477781	Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.	Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization.	0.998