node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNK | LHX1 | ENSP00000374529 | ENSP00000477829 | Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | 0.840 |
EVX1 | LHX1 | ENSP00000419266 | ENSP00000477829 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | 0.757 |
EVX1 | PAX2 | ENSP00000419266 | ENSP00000359319 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS. | 0.492 |
EVX1 | RAB2A | ENSP00000419266 | ENSP00000262646 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. | 0.564 |
LDB1 | LHX1 | ENSP00000501277 | ENSP00000477829 | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). Belongs to the LDB family. | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | 0.933 |
LDB1 | NEUROG2 | ENSP00000501277 | ENSP00000317333 | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). Belongs to the LDB family. | Neurogenin-2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3'). | 0.780 |
LDB1 | NKX2-2 | ENSP00000501277 | ENSP00000366347 | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). Belongs to the LDB family. | Homeobox protein Nkx-2.2; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity); Belongs to the NK-2 homeobox family. | 0.503 |
LDB1 | RAB2A | ENSP00000501277 | ENSP00000262646 | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). Belongs to the LDB family. | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. | 0.607 |
LDB1 | SSBP3 | ENSP00000501277 | ENSP00000360371 | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). Belongs to the LDB family. | Single-stranded DNA-binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. | 0.984 |
LDB1 | SSBP4 | ENSP00000501277 | ENSP00000270061 | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). Belongs to the LDB family. | Single stranded DNA binding protein 4. | 0.950 |
LDB2 | LHX1 | ENSP00000306772 | ENSP00000477829 | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | 0.861 |
LDB2 | NEUROG2 | ENSP00000306772 | ENSP00000317333 | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. | Neurogenin-2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3'). | 0.518 |
LDB2 | NKX2-2 | ENSP00000306772 | ENSP00000366347 | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. | Homeobox protein Nkx-2.2; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity); Belongs to the NK-2 homeobox family. | 0.480 |
LDB2 | PAX2 | ENSP00000306772 | ENSP00000359319 | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS. | 0.409 |
LDB2 | SSBP3 | ENSP00000306772 | ENSP00000360371 | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. | Single-stranded DNA-binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. | 0.887 |
LDB2 | SSBP4 | ENSP00000306772 | ENSP00000270061 | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. | Single stranded DNA binding protein 4. | 0.659 |
LHX1 | CCNK | ENSP00000477829 | ENSP00000374529 | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). | 0.840 |
LHX1 | EVX1 | ENSP00000477829 | ENSP00000419266 | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. | 0.757 |
LHX1 | LDB1 | ENSP00000477829 | ENSP00000501277 | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity). Belongs to the LDB family. | 0.933 |
LHX1 | LDB2 | ENSP00000477829 | ENSP00000306772 | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis. | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. | 0.861 |