STRINGSTRING
PLCL2 protein (human) - STRING interaction network
"PLCL2" - Inactive phospholipase C-like protein 2 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
PLCL2Inactive phospholipase C-like protein 2; May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum; C2 domain containing phospholipases (1127 aa)    
Predicted Functional Partners:
MTHFS
5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (203 aa)
       
      0.685
SLC35F5
Solute carrier family 35 member F5; Putative solute transporter; Belongs to the SLC35F solute transporter family (523 aa)
     
      0.617
SHOC2
Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the ’Ser-259’ inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes (582 aa)
       
      0.616
PPP1CC
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] (337 aa)
     
 
  0.583
PPP1CA
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] (341 aa)
     
 
  0.582
LRRC3B
Leucine-rich repeat-containing protein 3B; Leucine rich repeat containing 3B (259 aa)
     
 
  0.487
TTC21A
Tetratricopeptide repeat domain containing; Belongs to the TTC21 family (1320 aa)
           
  0.472
ZNF530
Zinc finger protein 530; May be involved in transcriptional regulation; Zinc fingers C2H2-type (599 aa)
           
  0.471
ZPLD1
Zona pellucida-like domain-containing protein 1; Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ (431 aa)
           
  0.466
FGD5
FYVE, RhoGEF and PH domain-containing protein 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape; Pleckstrin homology domain containing (1462 aa)
     
   
  0.440
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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