ICA1L protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI3BP	ICA1L	ENSP00000284322	ENSP00000478645	Target of Nesh-SH3; ABI family member 3 binding protein.	Islet cell autoantigen 1 like.	0.553
CYP20A1	GK5	ENSP00000348380	ENSP00000418001	Cytochrome P450 family 20 subfamily A member 1.	Glycerol kinase 5.	0.522
CYP20A1	ICA1L	ENSP00000348380	ENSP00000478645	Cytochrome P450 family 20 subfamily A member 1.	Islet cell autoantigen 1 like.	0.568
CYP20A1	NBEAL1	ENSP00000348380	ENSP00000399903	Cytochrome P450 family 20 subfamily A member 1.	Neurobeachin-like protein 1; Neurobeachin like 1; Belongs to the WD repeat neurobeachin family.	0.587
FAM117B	ICA1L	ENSP00000376071	ENSP00000478645	Protein FAM117B; Family with sequence similarity 117 member B.	Islet cell autoantigen 1 like.	0.690
FAM117B	NBEAL1	ENSP00000376071	ENSP00000399903	Protein FAM117B; Family with sequence similarity 117 member B.	Neurobeachin-like protein 1; Neurobeachin like 1; Belongs to the WD repeat neurobeachin family.	0.625
FAM117B	WDR12	ENSP00000376071	ENSP00000261015	Protein FAM117B; Family with sequence similarity 117 member B.	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.429
GFAP	ICA1L	ENSP00000253408	ENSP00000478645	Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.	Islet cell autoantigen 1 like.	0.533
GK5	CYP20A1	ENSP00000418001	ENSP00000348380	Glycerol kinase 5.	Cytochrome P450 family 20 subfamily A member 1.	0.522
GK5	ICA1L	ENSP00000418001	ENSP00000478645	Glycerol kinase 5.	Islet cell autoantigen 1 like.	0.539
ICA1L	ABI3BP	ENSP00000478645	ENSP00000284322	Islet cell autoantigen 1 like.	Target of Nesh-SH3; ABI family member 3 binding protein.	0.553
ICA1L	CYP20A1	ENSP00000478645	ENSP00000348380	Islet cell autoantigen 1 like.	Cytochrome P450 family 20 subfamily A member 1.	0.568
ICA1L	FAM117B	ENSP00000478645	ENSP00000376071	Islet cell autoantigen 1 like.	Protein FAM117B; Family with sequence similarity 117 member B.	0.690
ICA1L	GFAP	ENSP00000478645	ENSP00000253408	Islet cell autoantigen 1 like.	Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.	0.533
ICA1L	GK5	ENSP00000478645	ENSP00000418001	Islet cell autoantigen 1 like.	Glycerol kinase 5.	0.539
ICA1L	NBEAL1	ENSP00000478645	ENSP00000399903	Islet cell autoantigen 1 like.	Neurobeachin-like protein 1; Neurobeachin like 1; Belongs to the WD repeat neurobeachin family.	0.723
ICA1L	PICK1	ENSP00000478645	ENSP00000385205	Islet cell autoantigen 1 like.	PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...]	0.819
ICA1L	SNX32	ENSP00000478645	ENSP00000310620	Islet cell autoantigen 1 like.	Sorting nexin-32; May be involved in several stages of intracellular trafficking.	0.517
ICA1L	TOM1L2	ENSP00000478645	ENSP00000368818	Islet cell autoantigen 1 like.	TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling.	0.506
ICA1L	WDR12	ENSP00000478645	ENSP00000261015	Islet cell autoantigen 1 like.	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.567