STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ICA1LIslet cell autoantigen 1 like. (482 aa)    
Predicted Functional Partners:
PICK1
PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...]
    
 
 0.801
NBEAL1
Neurobeachin-like protein 1; Neurobeachin like 1; Belongs to the WD repeat neurobeachin family.
   
  
 0.693
FAM117B
Protein FAM117B; Family with sequence similarity 117 member B.
   
  
 0.655
WDR12
Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
      
 0.571
RTF2
Replication termination factor 2; Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA ; Belongs to the rtf2 family.
      
 0.561
GK5
Glycerol kinase 5.
   
  
 0.552
SNX32
Sorting nexin-32; May be involved in several stages of intracellular trafficking.
      
 0.551
CYP20A1
Cytochrome P450 family 20 subfamily A member 1.
   
 
 0.551
ZCCHC14
Zinc finger CCHC-type containing 14.
      
 0.506
OPA3
Outer mitochondrial membrane lipid metabolism regulator OPA3.
      
 0.504
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.