CNTNAP3B protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AASDHPPT	CNTNAP3	ENSP00000278618	ENSP00000297668	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.	Contactin-associated protein-like 3; Contactin associated protein family member 3.	0.593
AASDHPPT	CNTNAP3B	ENSP00000278618	ENSP00000478671	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	0.591
CD1B	CNTNAP3B	ENSP00000357150	ENSP00000478671	T-cell surface glycoprotein CD1b; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	0.518
CNTNAP3	AASDHPPT	ENSP00000297668	ENSP00000278618	Contactin-associated protein-like 3; Contactin associated protein family member 3.	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.	0.593
CNTNAP3	CNTNAP3B	ENSP00000297668	ENSP00000478671	Contactin-associated protein-like 3; Contactin associated protein family member 3.	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	0.983
CNTNAP3B	AASDHPPT	ENSP00000478671	ENSP00000278618	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.	0.591
CNTNAP3B	CD1B	ENSP00000478671	ENSP00000357150	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	T-cell surface glycoprotein CD1b; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.	0.518
CNTNAP3B	CNTNAP3	ENSP00000478671	ENSP00000297668	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	Contactin-associated protein-like 3; Contactin associated protein family member 3.	0.983
CNTNAP3B	DNAJC3	ENSP00000478671	ENSP00000473631	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF [...]	0.432
CNTNAP3B	HSP90AA1	ENSP00000478671	ENSP00000335153	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.566
CNTNAP3B	OR7G1	ENSP00000478671	ENSP00000444134	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	Olfactory receptor 7G1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	0.428
CNTNAP3B	PRAMEF18	ENSP00000478671	ENSP00000485473	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	PRAME family member 18; Belongs to the PRAME family.	0.438
CNTNAP3B	SMPD1	ENSP00000478671	ENSP00000340409	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 3 lacks residues that bind the cofactor Zn(2+) and has no enzyme activity; Belongs to the acid sphingomyelinase family.	0.560
DNAJC3	CNTNAP3B	ENSP00000473631	ENSP00000478671	DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF [...]	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	0.432
DNAJC3	HSP90AA1	ENSP00000473631	ENSP00000335153	DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF [...]	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.492
HSP90AA1	CNTNAP3B	ENSP00000335153	ENSP00000478671	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	0.566
HSP90AA1	DNAJC3	ENSP00000335153	ENSP00000473631	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF [...]	0.492
OR7G1	CNTNAP3B	ENSP00000444134	ENSP00000478671	Olfactory receptor 7G1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	0.428
PRAMEF18	CNTNAP3B	ENSP00000485473	ENSP00000478671	PRAME family member 18; Belongs to the PRAME family.	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	0.438
SMPD1	CNTNAP3B	ENSP00000340409	ENSP00000478671	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 3 lacks residues that bind the cofactor Zn(2+) and has no enzyme activity; Belongs to the acid sphingomyelinase family.	Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.	0.560