node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASCC1 | LENG9 | ENSP00000339404 | ENSP00000479355 | Activating signal cointegrator 1 complex subunit 1; Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF- kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. | Leukocyte receptor cluster member 9. | 0.417 |
CARNMT1 | LENG9 | ENSP00000366030 | ENSP00000479355 | Carnosine N-methyltransferase; N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). | Leukocyte receptor cluster member 9. | 0.465 |
CDC42EP5 | LENG8 | ENSP00000301200 | ENSP00000318374 | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity); Belongs to the BORG/CEP family. | Leukocyte receptor cluster member 8. | 0.672 |
CDC42EP5 | LENG9 | ENSP00000301200 | ENSP00000479355 | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity); Belongs to the BORG/CEP family. | Leukocyte receptor cluster member 9. | 0.644 |
CDC42EP5 | TTYH1 | ENSP00000301200 | ENSP00000365714 | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity); Belongs to the BORG/CEP family. | Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion (By similarity); Belongs to the tweety family. | 0.617 |
DENND10 | LENG9 | ENSP00000354688 | ENSP00000479355 | DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP- bound form; Belongs to the DENND10 family. | Leukocyte receptor cluster member 9. | 0.442 |
LENG1 | LENG9 | ENSP00000222224 | ENSP00000479355 | Leukocyte receptor cluster member 1. | Leukocyte receptor cluster member 9. | 0.456 |
LENG8 | CDC42EP5 | ENSP00000318374 | ENSP00000301200 | Leukocyte receptor cluster member 8. | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity); Belongs to the BORG/CEP family. | 0.672 |
LENG8 | LENG9 | ENSP00000318374 | ENSP00000479355 | Leukocyte receptor cluster member 8. | Leukocyte receptor cluster member 9. | 0.621 |
LENG8 | TTYH1 | ENSP00000318374 | ENSP00000365714 | Leukocyte receptor cluster member 8. | Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion (By similarity); Belongs to the tweety family. | 0.648 |
LENG9 | ASCC1 | ENSP00000479355 | ENSP00000339404 | Leukocyte receptor cluster member 9. | Activating signal cointegrator 1 complex subunit 1; Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF- kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. | 0.417 |
LENG9 | CARNMT1 | ENSP00000479355 | ENSP00000366030 | Leukocyte receptor cluster member 9. | Carnosine N-methyltransferase; N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). | 0.465 |
LENG9 | CDC42EP5 | ENSP00000479355 | ENSP00000301200 | Leukocyte receptor cluster member 9. | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity); Belongs to the BORG/CEP family. | 0.644 |
LENG9 | DENND10 | ENSP00000479355 | ENSP00000354688 | Leukocyte receptor cluster member 9. | DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP- bound form; Belongs to the DENND10 family. | 0.442 |
LENG9 | LENG1 | ENSP00000479355 | ENSP00000222224 | Leukocyte receptor cluster member 9. | Leukocyte receptor cluster member 1. | 0.456 |
LENG9 | LENG8 | ENSP00000479355 | ENSP00000318374 | Leukocyte receptor cluster member 9. | Leukocyte receptor cluster member 8. | 0.621 |
LENG9 | PHYHIP | ENSP00000479355 | ENSP00000320017 | Leukocyte receptor cluster member 9. | Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system. | 0.416 |
LENG9 | TMCO4 | ENSP00000479355 | ENSP00000294543 | Leukocyte receptor cluster member 9. | Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family. | 0.423 |
LENG9 | TTYH1 | ENSP00000479355 | ENSP00000365714 | Leukocyte receptor cluster member 9. | Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion (By similarity); Belongs to the tweety family. | 0.551 |
LENG9 | ZC3HAV1L | ENSP00000479355 | ENSP00000275766 | Leukocyte receptor cluster member 9. | Zinc finger CCCH-type containing, antiviral 1 like. | 0.428 |