node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASCC2 | GUCD1 | ENSP00000380877 | ENSP00000479370 | Activating signal cointegrator 1 complex subunit 2; Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF- kappa-B, SRF and AP1 transactivation. | Protein GUCD1; Guanylyl cyclase domain containing 1. | 0.602 |
C22orf15 | GUCD1 | ENSP00000305096 | ENSP00000479370 | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15. | Protein GUCD1; Guanylyl cyclase domain containing 1. | 0.580 |
C22orf15 | LRRC75B | ENSP00000305096 | ENSP00000320520 | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15. | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | 0.718 |
DCTN4 | GUCD1 | ENSP00000414906 | ENSP00000479370 | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | Protein GUCD1; Guanylyl cyclase domain containing 1. | 0.512 |
GUCD1 | ASCC2 | ENSP00000479370 | ENSP00000380877 | Protein GUCD1; Guanylyl cyclase domain containing 1. | Activating signal cointegrator 1 complex subunit 2; Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF- kappa-B, SRF and AP1 transactivation. | 0.602 |
GUCD1 | C22orf15 | ENSP00000479370 | ENSP00000305096 | Protein GUCD1; Guanylyl cyclase domain containing 1. | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15. | 0.580 |
GUCD1 | DCTN4 | ENSP00000479370 | ENSP00000414906 | Protein GUCD1; Guanylyl cyclase domain containing 1. | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. | 0.512 |
GUCD1 | LCE2B | ENSP00000479370 | ENSP00000357769 | Protein GUCD1; Guanylyl cyclase domain containing 1. | Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum. | 0.591 |
GUCD1 | LRRC75B | ENSP00000479370 | ENSP00000320520 | Protein GUCD1; Guanylyl cyclase domain containing 1. | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | 0.652 |
GUCD1 | MTMR8 | ENSP00000479370 | ENSP00000363985 | Protein GUCD1; Guanylyl cyclase domain containing 1. | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate. In complex with MTMR9, negatively regulates autophagy. | 0.593 |
GUCD1 | SLC25A39 | ENSP00000479370 | ENSP00000366299 | Protein GUCD1; Guanylyl cyclase domain containing 1. | Solute carrier family 25 member 39; Required for normal heme biosynthesis; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.556 |
GUCD1 | STRADB | ENSP00000479370 | ENSP00000194530 | Protein GUCD1; Guanylyl cyclase domain containing 1. | STE20-related kinase adapter protein beta; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). | 0.540 |
GUCD1 | UBXN6 | ENSP00000479370 | ENSP00000301281 | Protein GUCD1; Guanylyl cyclase domain containing 1. | UBX domain-containing protein 6; May negatively regulate the ATPase activity of VCP, an ATP- driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. | 0.539 |
GUCD1 | ZNF652 | ENSP00000479370 | ENSP00000354686 | Protein GUCD1; Guanylyl cyclase domain containing 1. | Zinc finger protein 652; Functions as a transcriptional repressor. | 0.606 |
LCE2B | GUCD1 | ENSP00000357769 | ENSP00000479370 | Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum. | Protein GUCD1; Guanylyl cyclase domain containing 1. | 0.591 |
LRRC75B | C22orf15 | ENSP00000320520 | ENSP00000305096 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15. | 0.718 |
LRRC75B | GUCD1 | ENSP00000320520 | ENSP00000479370 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | Protein GUCD1; Guanylyl cyclase domain containing 1. | 0.652 |
MTMR8 | GUCD1 | ENSP00000363985 | ENSP00000479370 | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate. In complex with MTMR9, negatively regulates autophagy. | Protein GUCD1; Guanylyl cyclase domain containing 1. | 0.593 |
SLC25A39 | GUCD1 | ENSP00000366299 | ENSP00000479370 | Solute carrier family 25 member 39; Required for normal heme biosynthesis; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Protein GUCD1; Guanylyl cyclase domain containing 1. | 0.556 |
SLC25A39 | STRADB | ENSP00000366299 | ENSP00000194530 | Solute carrier family 25 member 39; Required for normal heme biosynthesis; Belongs to the mitochondrial carrier (TC 2.A.29) family. | STE20-related kinase adapter protein beta; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). | 0.689 |