node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GABARAPL2 | GIMAP6 | ENSP00000037243 | ENSP00000479580 | Gamma-aminobutyric acid receptor-associated protein-like 2; Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved [...] | GTPase, IMAP family member 6. | 0.750 |
GIMAP1 | GIMAP4 | ENSP00000302833 | ENSP00000419545 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.818 |
GIMAP1 | GIMAP5 | ENSP00000302833 | ENSP00000351473 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | 0.710 |
GIMAP1 | GIMAP6 | ENSP00000302833 | ENSP00000479580 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase, IMAP family member 6. | 0.827 |
GIMAP1 | GIMAP7 | ENSP00000302833 | ENSP00000315474 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase IMAP family member 7; The dimer has GTPase activity; the active site contains residues from both subunits. | 0.833 |
GIMAP1 | GIMAP8 | ENSP00000302833 | ENSP00000305107 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. | 0.893 |
GIMAP1 | TMEM176B | ENSP00000302833 | ENSP00000410269 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | Transmembrane protein 176B; May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). | 0.421 |
GIMAP1-GIMAP5 | GIMAP4 | ENSP00000477920 | ENSP00000419545 | GIMAP1-GIMAP5 readthrough. | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | 0.525 |
GIMAP1-GIMAP5 | GIMAP5 | ENSP00000477920 | ENSP00000351473 | GIMAP1-GIMAP5 readthrough. | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | 0.802 |
GIMAP1-GIMAP5 | GIMAP6 | ENSP00000477920 | ENSP00000479580 | GIMAP1-GIMAP5 readthrough. | GTPase, IMAP family member 6. | 0.749 |
GIMAP1-GIMAP5 | GIMAP7 | ENSP00000477920 | ENSP00000315474 | GIMAP1-GIMAP5 readthrough. | GTPase IMAP family member 7; The dimer has GTPase activity; the active site contains residues from both subunits. | 0.576 |
GIMAP1-GIMAP5 | GIMAP8 | ENSP00000477920 | ENSP00000305107 | GIMAP1-GIMAP5 readthrough. | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. | 0.612 |
GIMAP4 | GIMAP1 | ENSP00000419545 | ENSP00000302833 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | 0.818 |
GIMAP4 | GIMAP1-GIMAP5 | ENSP00000419545 | ENSP00000477920 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GIMAP1-GIMAP5 readthrough. | 0.525 |
GIMAP4 | GIMAP5 | ENSP00000419545 | ENSP00000351473 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | 0.898 |
GIMAP4 | GIMAP6 | ENSP00000419545 | ENSP00000479580 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GTPase, IMAP family member 6. | 0.907 |
GIMAP4 | GIMAP7 | ENSP00000419545 | ENSP00000315474 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GTPase IMAP family member 7; The dimer has GTPase activity; the active site contains residues from both subunits. | 0.929 |
GIMAP4 | GIMAP8 | ENSP00000419545 | ENSP00000305107 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections. | 0.911 |
GIMAP4 | TMEM176B | ENSP00000419545 | ENSP00000410269 | GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP. | Transmembrane protein 176B; May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). | 0.474 |
GIMAP5 | GIMAP1 | ENSP00000351473 | ENSP00000302833 | GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the [...] | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). | 0.710 |