RAPGEFL1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMZ1	RAPGEFL1	ENSP00000308149	ENSP00000479735	Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family.	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	0.427
ATP8B2	FAM118A	ENSP00000500034	ENSP00000216214	Phospholipid-transporting ATPase ID; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Protein FAM118A; Family with sequence similarity 118 member A.	0.488
ATP8B2	RAPGEFL1	ENSP00000500034	ENSP00000479735	Phospholipid-transporting ATPase ID; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	0.483
ATP8B2	RNFT2	ENSP00000500034	ENSP00000257575	Phospholipid-transporting ATPase ID; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	Ring finger protein, transmembrane 2.	0.403
FAM118A	ATP8B2	ENSP00000216214	ENSP00000500034	Protein FAM118A; Family with sequence similarity 118 member A.	Phospholipid-transporting ATPase ID; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.488
FAM118A	LAPTM4A	ENSP00000216214	ENSP00000175091	Protein FAM118A; Family with sequence similarity 118 member A.	Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.	0.452
FAM118A	RAPGEFL1	ENSP00000216214	ENSP00000479735	Protein FAM118A; Family with sequence similarity 118 member A.	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	0.536
FAM118A	RNFT2	ENSP00000216214	ENSP00000257575	Protein FAM118A; Family with sequence similarity 118 member A.	Ring finger protein, transmembrane 2.	0.430
GPRIN1	RAPGEFL1	ENSP00000305839	ENSP00000479735	G protein-regulated inducer of neurite outgrowth 1; May be involved in neurite outgrowth.	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	0.431
GPRIN1	RNFT2	ENSP00000305839	ENSP00000257575	G protein-regulated inducer of neurite outgrowth 1; May be involved in neurite outgrowth.	Ring finger protein, transmembrane 2.	0.414
LAPTM4A	FAM118A	ENSP00000175091	ENSP00000216214	Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.	Protein FAM118A; Family with sequence similarity 118 member A.	0.452
LAPTM4A	RAPGEFL1	ENSP00000175091	ENSP00000479735	Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	0.471
OGFOD3	RAPGEFL1	ENSP00000330075	ENSP00000479735	2-oxoglutarate and iron dependent oxygenase domain containing 3; Belongs to the OGFOD3 family.	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	0.500
RAPGEFL1	AMZ1	ENSP00000479735	ENSP00000308149	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family.	0.427
RAPGEFL1	ATP8B2	ENSP00000479735	ENSP00000500034	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	Phospholipid-transporting ATPase ID; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.	0.483
RAPGEFL1	FAM118A	ENSP00000479735	ENSP00000216214	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	Protein FAM118A; Family with sequence similarity 118 member A.	0.536
RAPGEFL1	GPRIN1	ENSP00000479735	ENSP00000305839	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	G protein-regulated inducer of neurite outgrowth 1; May be involved in neurite outgrowth.	0.431
RAPGEFL1	LAPTM4A	ENSP00000479735	ENSP00000175091	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.	0.471
RAPGEFL1	OGFOD3	ENSP00000479735	ENSP00000330075	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	2-oxoglutarate and iron dependent oxygenase domain containing 3; Belongs to the OGFOD3 family.	0.500
RAPGEFL1	RNFT2	ENSP00000479735	ENSP00000257575	Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).	Ring finger protein, transmembrane 2.	0.439