| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BEST1 | MFRP | ENSP00000399709 | ENSP00000481824 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Membrane frizzled-related protein; May play a role in eye development. | 0.522 |
| BEST1 | PRSS56 | ENSP00000399709 | ENSP00000479745 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Serine protease 56; Serine protease required during eye development. | 0.544 |
| BEST1 | RDH5 | ENSP00000399709 | ENSP00000257895 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Retinol dehydrogenase 5; Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.495 |
| BEST1 | TMEM98 | ENSP00000399709 | ENSP00000463245 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). | 0.562 |
| GJD2 | KCNQ5 | ENSP00000290374 | ENSP00000345055 | Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Delta-type subfamily. | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current [...] | 0.443 |
| GJD2 | LAMA2 | ENSP00000290374 | ENSP00000400365 | Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Delta-type subfamily. | Laminin subunit alpha-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | 0.436 |
| GJD2 | PRSS56 | ENSP00000290374 | ENSP00000479745 | Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Delta-type subfamily. | Serine protease 56; Serine protease required during eye development. | 0.525 |
| KCNQ5 | GJD2 | ENSP00000345055 | ENSP00000290374 | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current [...] | Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Delta-type subfamily. | 0.443 |
| KCNQ5 | LAMA2 | ENSP00000345055 | ENSP00000400365 | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current [...] | Laminin subunit alpha-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | 0.454 |
| KCNQ5 | PRSS56 | ENSP00000345055 | ENSP00000479745 | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current [...] | Serine protease 56; Serine protease required during eye development. | 0.584 |
| KCNQ5 | RDH5 | ENSP00000345055 | ENSP00000257895 | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current [...] | Retinol dehydrogenase 5; Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.451 |
| LAMA2 | GJD2 | ENSP00000400365 | ENSP00000290374 | Laminin subunit alpha-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Delta-type subfamily. | 0.436 |
| LAMA2 | KCNQ5 | ENSP00000400365 | ENSP00000345055 | Laminin subunit alpha-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current [...] | 0.454 |
| LAMA2 | PRSS56 | ENSP00000400365 | ENSP00000479745 | Laminin subunit alpha-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | Serine protease 56; Serine protease required during eye development. | 0.551 |
| LAMA2 | RDH5 | ENSP00000400365 | ENSP00000257895 | Laminin subunit alpha-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | Retinol dehydrogenase 5; Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.408 |
| MFRP | BEST1 | ENSP00000481824 | ENSP00000399709 | Membrane frizzled-related protein; May play a role in eye development. | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | 0.522 |
| MFRP | PRSS56 | ENSP00000481824 | ENSP00000479745 | Membrane frizzled-related protein; May play a role in eye development. | Serine protease 56; Serine protease required during eye development. | 0.762 |
| MFRP | TMEM98 | ENSP00000481824 | ENSP00000463245 | Membrane frizzled-related protein; May play a role in eye development. | Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). | 0.724 |
| PRSS56 | BEST1 | ENSP00000479745 | ENSP00000399709 | Serine protease 56; Serine protease required during eye development. | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. | 0.544 |
| PRSS56 | GJD2 | ENSP00000479745 | ENSP00000290374 | Serine protease 56; Serine protease required during eye development. | Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Delta-type subfamily. | 0.525 |
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