node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNTD2 | NAT9 | ENSP00000396755 | ENSP00000462835 | Cyclin N-terminal domain-containing protein 2. | N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily. | 0.456 |
CNTD2 | ZNF205 | ENSP00000396755 | ENSP00000480401 | Cyclin N-terminal domain-containing protein 2. | Zinc finger protein 205; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.479 |
COQ9 | NAT9 | ENSP00000262507 | ENSP00000462835 | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7; Belongs to the COQ9 family. | N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily. | 0.608 |
COQ9 | NEU2 | ENSP00000262507 | ENSP00000233840 | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7; Belongs to the COQ9 family. | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides. | 0.429 |
COQ9 | SVOPL | ENSP00000262507 | ENSP00000405482 | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7; Belongs to the COQ9 family. | Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily. | 0.623 |
COQ9 | ZNF205 | ENSP00000262507 | ENSP00000480401 | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7; Belongs to the COQ9 family. | Zinc finger protein 205; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.540 |
GCGR | NAT9 | ENSP00000383558 | ENSP00000462835 | Glucagon receptor; G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signal [...] | N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily. | 0.421 |
GCGR | ZNF205 | ENSP00000383558 | ENSP00000480401 | Glucagon receptor; G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signal [...] | Zinc finger protein 205; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.473 |
MEFV | OR1F1 | ENSP00000219596 | ENSP00000305424 | Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it [...] | Olfactory receptor 1F1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.778 |
MEFV | ZNF205 | ENSP00000219596 | ENSP00000480401 | Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it [...] | Zinc finger protein 205; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.732 |
NAT9 | CNTD2 | ENSP00000462835 | ENSP00000396755 | N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily. | Cyclin N-terminal domain-containing protein 2. | 0.456 |
NAT9 | COQ9 | ENSP00000462835 | ENSP00000262507 | N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily. | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7; Belongs to the COQ9 family. | 0.608 |
NAT9 | GCGR | ENSP00000462835 | ENSP00000383558 | N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily. | Glucagon receptor; G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signal [...] | 0.421 |
NAT9 | NEU2 | ENSP00000462835 | ENSP00000233840 | N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily. | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides. | 0.498 |
NAT9 | SVOPL | ENSP00000462835 | ENSP00000405482 | N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily. | Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily. | 0.613 |
NAT9 | ZNF205 | ENSP00000462835 | ENSP00000480401 | N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily. | Zinc finger protein 205; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.521 |
NEU2 | COQ9 | ENSP00000233840 | ENSP00000262507 | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides. | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7; Belongs to the COQ9 family. | 0.429 |
NEU2 | NAT9 | ENSP00000233840 | ENSP00000462835 | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides. | N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily. | 0.498 |
NEU2 | SVOPL | ENSP00000233840 | ENSP00000405482 | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides. | Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily. | 0.487 |
NEU2 | ZNF205 | ENSP00000233840 | ENSP00000480401 | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides. | Zinc finger protein 205; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.522 |