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ENSG00000255819 protein (human) - STRING interaction network
"ENSG00000255819" - NKG2-D type II integral membrane protein in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ENSG00000255819NKG2-D type II integral membrane protein; Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expre [...] (216 aa)    
Predicted Functional Partners:
MICA
MHC class I polypeptide-related sequence A; Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T- cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis; Belongs to the MHC class I family. MIC subfamily (332 aa)
       
  0.999
ULBP3
UL16-binding protein 3; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity (244 aa)
       
  0.994
RAET1E
Retinoic acid early transcript 1E; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity (263 aa)
         
  0.987
MICB
MHC class I polypeptide-related sequence B; Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis; Belongs to the MHC class I family. MIC subfamily (383 aa)
         
  0.987
RAET1L
UL16-binding protein 6; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity (246 aa)
       
  0.986
ULBP2
UL16-binding protein 2; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity; Belongs to the MHC class I family (246 aa)
         
  0.982
HCST
Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigge [...] (93 aa)
     
  0.976
ULBP1
UL16-binding protein 1; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity; Belongs to the MHC class I family (244 aa)
         
  0.972
RAET1G
UL-16 binding protein 5; Isoform 1- Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity (334 aa)
         
  0.935
IL15
Interleukin-15; Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha; Belongs to the IL-15/IL-21 family (162 aa)
     
   
  0.921
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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