| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACACA | FNDC11 | ENSP00000483300 | ENSP00000480914 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Fibronectin type III domain containing 11. | 0.562 |
| AKR7A3 | FNDC11 | ENSP00000355377 | ENSP00000480914 | Aflatoxin B1 aldehyde reductase member 3; Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. | Fibronectin type III domain containing 11. | 0.783 |
| AKR7A3 | HOGA1 | ENSP00000355377 | ENSP00000359680 | Aflatoxin B1 aldehyde reductase member 3; Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline; Belongs to the DapA family. | 0.833 |
| ARL5B | FNDC11 | ENSP00000366487 | ENSP00000480914 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP. | Fibronectin type III domain containing 11. | 0.437 |
| EMB | FNDC11 | ENSP00000302289 | ENSP00000480914 | Embigin; Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). | Fibronectin type III domain containing 11. | 0.648 |
| FNDC11 | ACACA | ENSP00000480914 | ENSP00000483300 | Fibronectin type III domain containing 11. | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | 0.562 |
| FNDC11 | AKR7A3 | ENSP00000480914 | ENSP00000355377 | Fibronectin type III domain containing 11. | Aflatoxin B1 aldehyde reductase member 3; Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. | 0.783 |
| FNDC11 | ARL5B | ENSP00000480914 | ENSP00000366487 | Fibronectin type III domain containing 11. | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP. | 0.437 |
| FNDC11 | EMB | ENSP00000480914 | ENSP00000302289 | Fibronectin type III domain containing 11. | Embigin; Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). | 0.648 |
| FNDC11 | GMEB2 | ENSP00000480914 | ENSP00000266068 | Fibronectin type III domain containing 11. | Glucocorticoid modulatory element-binding protein 2; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. | 0.442 |
| FNDC11 | GPBP1 | ENSP00000480914 | ENSP00000401596 | Fibronectin type III domain containing 11. | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family. | 0.946 |
| FNDC11 | HOGA1 | ENSP00000480914 | ENSP00000359680 | Fibronectin type III domain containing 11. | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline; Belongs to the DapA family. | 0.459 |
| FNDC11 | MEX3A | ENSP00000480914 | ENSP00000432845 | Fibronectin type III domain containing 11. | RNA-binding protein MEX3A; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. | 0.457 |
| FNDC11 | STXBP4 | ENSP00000480914 | ENSP00000365530 | Fibronectin type III domain containing 11. | Syntaxin-binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). | 0.645 |
| FNDC11 | ZGPAT | ENSP00000480914 | ENSP00000332013 | Fibronectin type III domain containing 11. | Zinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. | 0.442 |
| GMEB2 | FNDC11 | ENSP00000266068 | ENSP00000480914 | Glucocorticoid modulatory element-binding protein 2; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. | Fibronectin type III domain containing 11. | 0.442 |
| GMEB2 | ZGPAT | ENSP00000266068 | ENSP00000332013 | Glucocorticoid modulatory element-binding protein 2; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. | Zinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. | 0.612 |
| GPBP1 | FNDC11 | ENSP00000401596 | ENSP00000480914 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family. | Fibronectin type III domain containing 11. | 0.946 |
| HOGA1 | AKR7A3 | ENSP00000359680 | ENSP00000355377 | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline; Belongs to the DapA family. | Aflatoxin B1 aldehyde reductase member 3; Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. | 0.833 |
| HOGA1 | FNDC11 | ENSP00000359680 | ENSP00000480914 | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline; Belongs to the DapA family. | Fibronectin type III domain containing 11. | 0.459 |