| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CPLX2 | HPCAL4 | ENSP00000352544 | ENSP00000481834 | Complexin-2; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity). Belongs to the complexin/synaphin family. | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | 0.617 |
| CPLX2 | SNAP25 | ENSP00000352544 | ENSP00000254976 | Complexin-2; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity). Belongs to the complexin/synaphin family. | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Belongs to the SNAP-25 family. | 0.988 |
| CYP1A1 | HPCAL4 | ENSP00000378488 | ENSP00000481834 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | 0.531 |
| FAM131C | HPCAL4 | ENSP00000364814 | ENSP00000481834 | Protein FAM131C; Family with sequence similarity 131 member C. | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | 0.961 |
| FAM131C | VSNL1 | ENSP00000364814 | ENSP00000384719 | Protein FAM131C; Family with sequence similarity 131 member C. | Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family. | 0.826 |
| FBXL16 | HPCAL4 | ENSP00000380746 | ENSP00000481834 | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | 0.578 |
| HPCAL4 | CPLX2 | ENSP00000481834 | ENSP00000352544 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | Complexin-2; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity). Belongs to the complexin/synaphin family. | 0.617 |
| HPCAL4 | CYP1A1 | ENSP00000481834 | ENSP00000378488 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.531 |
| HPCAL4 | FAM131C | ENSP00000481834 | ENSP00000364814 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | Protein FAM131C; Family with sequence similarity 131 member C. | 0.961 |
| HPCAL4 | FBXL16 | ENSP00000481834 | ENSP00000380746 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.578 |
| HPCAL4 | LSAMP | ENSP00000481834 | ENSP00000419000 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | Limbic system-associated membrane protein; Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity); Belongs to the immunoglobulin superfamily. IgLON family. | 0.514 |
| HPCAL4 | PI4KB | ENSP00000481834 | ENSP00000357869 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity). | 0.553 |
| HPCAL4 | SNAP25 | ENSP00000481834 | ENSP00000254976 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Belongs to the SNAP-25 family. | 0.604 |
| HPCAL4 | TSC22D3 | ENSP00000481834 | ENSP00000361458 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulati [...] | 0.656 |
| HPCAL4 | TTC12 | ENSP00000481834 | ENSP00000419652 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | Tetratricopeptide repeat domain 12. | 0.559 |
| HPCAL4 | VSNL1 | ENSP00000481834 | ENSP00000384719 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family. | 0.744 |
| LSAMP | HPCAL4 | ENSP00000419000 | ENSP00000481834 | Limbic system-associated membrane protein; Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity); Belongs to the immunoglobulin superfamily. IgLON family. | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | 0.514 |
| PI4KB | HPCAL4 | ENSP00000357869 | ENSP00000481834 | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity). | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. | 0.553 |
| PI4KB | VSNL1 | ENSP00000357869 | ENSP00000384719 | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity). | Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family. | 0.853 |
| SNAP25 | CPLX2 | ENSP00000254976 | ENSP00000352544 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Belongs to the SNAP-25 family. | Complexin-2; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity). Belongs to the complexin/synaphin family. | 0.988 |
