node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHCYL1 | AHCYL2 | ENSP00000358814 | ENSP00000315931 | S-adenosylhomocysteine hydrolase-like protein 1; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITP [...] | Adenosylhomocysteinase 3; May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate ; Belongs to the adenosylhomocysteinase family. | 0.964 |
AHCYL1 | FAM13C | ENSP00000358814 | ENSP00000481854 | S-adenosylhomocysteine hydrolase-like protein 1; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITP [...] | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | 0.622 |
AHCYL2 | AHCYL1 | ENSP00000315931 | ENSP00000358814 | Adenosylhomocysteinase 3; May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate ; Belongs to the adenosylhomocysteinase family. | S-adenosylhomocysteine hydrolase-like protein 1; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITP [...] | 0.964 |
AHCYL2 | FAM13C | ENSP00000315931 | ENSP00000481854 | Adenosylhomocysteinase 3; May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate ; Belongs to the adenosylhomocysteinase family. | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | 0.550 |
AZGP1 | FAM13C | ENSP00000292401 | ENSP00000481854 | Zinc-alpha-2-glycoprotein; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids; Belongs to the MHC class I family. | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | 0.571 |
AZGP1 | KLK2 | ENSP00000292401 | ENSP00000313581 | Zinc-alpha-2-glycoprotein; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids; Belongs to the MHC class I family. | Kallikrein-2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. | 0.428 |
AZGP1 | SRD5A2 | ENSP00000292401 | ENSP00000477587 | Zinc-alpha-2-glycoprotein; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids; Belongs to the MHC class I family. | 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.633 |
FAM13C | AHCYL1 | ENSP00000481854 | ENSP00000358814 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | S-adenosylhomocysteine hydrolase-like protein 1; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITP [...] | 0.622 |
FAM13C | AHCYL2 | ENSP00000481854 | ENSP00000315931 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | Adenosylhomocysteinase 3; May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate ; Belongs to the adenosylhomocysteinase family. | 0.550 |
FAM13C | AZGP1 | ENSP00000481854 | ENSP00000292401 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | Zinc-alpha-2-glycoprotein; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids; Belongs to the MHC class I family. | 0.571 |
FAM13C | FLNC | ENSP00000481854 | ENSP00000327145 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. | 0.492 |
FAM13C | GSTM2 | ENSP00000481854 | ENSP00000241337 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | Glutathione S-transferase Mu 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. | 0.507 |
FAM13C | KLK2 | ENSP00000481854 | ENSP00000313581 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | Kallikrein-2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily. | 0.506 |
FAM13C | SFRP4 | ENSP00000481854 | ENSP00000410715 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. | 0.520 |
FAM13C | SRD5A2 | ENSP00000481854 | ENSP00000477587 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. | 0.613 |
FAM13C | TPM2 | ENSP00000481854 | ENSP00000496494 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. | 0.490 |
FAM13C | TPX2 | ENSP00000481854 | ENSP00000300403 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | Targeting protein for Xklp2; Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates [...] | 0.506 |
FLNC | FAM13C | ENSP00000327145 | ENSP00000481854 | Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | 0.492 |
FLNC | TPM2 | ENSP00000327145 | ENSP00000496494 | Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. | Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. | 0.742 |
GSTM2 | FAM13C | ENSP00000241337 | ENSP00000481854 | Glutathione S-transferase Mu 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family. | 0.507 |