node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP11B-2 | ASPM | ENSP00000481934 | ENSP00000356379 | Rho GTPase activating protein 11B. | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | 0.741 |
ARHGAP11B-2 | CENPF | ENSP00000481934 | ENSP00000355922 | Rho GTPase activating protein 11B. | Centromere protein F; Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cy [...] | 0.658 |
ARHGAP11B-2 | FAM72B | ENSP00000481934 | ENSP00000358397 | Rho GTPase activating protein 11B. | Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family. | 0.666 |
ARHGAP11B-2 | FAM72C | ENSP00000481934 | ENSP00000463032 | Rho GTPase activating protein 11B. | Protein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family. | 0.665 |
ARHGAP11B-2 | KIF11 | ENSP00000481934 | ENSP00000260731 | Rho GTPase activating protein 11B. | Kinesin-like protein KIF11; Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface ; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily. | 0.680 |
ARHGAP11B-2 | MTMR10 | ENSP00000481934 | ENSP00000402537 | Rho GTPase activating protein 11B. | Myotubularin related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.673 |
ARHGAP11B-2 | NOTCH2NLA | ENSP00000481934 | ENSP00000354929 | Rho GTPase activating protein 11B. | Notch homolog 2 N-terminal-like protein A; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] | 0.704 |
ARHGAP11B-2 | NOTCH2NLB | ENSP00000481934 | ENSP00000472124 | Rho GTPase activating protein 11B. | Notch homolog 2 N-terminal-like protein B; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...] | 0.701 |
ARHGAP11B-2 | OTUD7A | ENSP00000481934 | ENSP00000305926 | Rho GTPase activating protein 11B. | OTU domain-containing protein 7A; Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains; Belongs to the peptidase C64 family. | 0.643 |
ARHGAP11B-2 | SRGAP2C | ENSP00000481934 | ENSP00000478290 | Rho GTPase activating protein 11B. | SLIT-ROBO Rho GTPase-activating protein 2C; Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory. | 0.720 |
ASPM | ARHGAP11B-2 | ENSP00000356379 | ENSP00000481934 | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | Rho GTPase activating protein 11B. | 0.741 |
ASPM | CENPF | ENSP00000356379 | ENSP00000355922 | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | Centromere protein F; Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cy [...] | 0.987 |
ASPM | KIF11 | ENSP00000356379 | ENSP00000260731 | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | Kinesin-like protein KIF11; Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface ; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily. | 0.989 |
CENPF | ARHGAP11B-2 | ENSP00000355922 | ENSP00000481934 | Centromere protein F; Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cy [...] | Rho GTPase activating protein 11B. | 0.658 |
CENPF | ASPM | ENSP00000355922 | ENSP00000356379 | Centromere protein F; Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cy [...] | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | 0.987 |
CENPF | KIF11 | ENSP00000355922 | ENSP00000260731 | Centromere protein F; Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cy [...] | Kinesin-like protein KIF11; Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface ; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily. | 0.972 |
FAM72B | ARHGAP11B-2 | ENSP00000358397 | ENSP00000481934 | Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family. | Rho GTPase activating protein 11B. | 0.666 |
FAM72B | FAM72C | ENSP00000358397 | ENSP00000463032 | Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family. | Protein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family. | 0.999 |
FAM72B | KIF11 | ENSP00000358397 | ENSP00000260731 | Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family. | Kinesin-like protein KIF11; Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface ; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily. | 0.400 |
FAM72B | MTMR10 | ENSP00000358397 | ENSP00000402537 | Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family. | Myotubularin related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.404 |