node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf95 | EPN1 | ENSP00000482180 | ENSP00000406209 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | Epsin-1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis; Belongs to the epsin family | 0.450 |
C11orf95 | FAM118B | ENSP00000482180 | ENSP00000433343 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | 0.688 |
C11orf95 | KIAA1549 | ENSP00000482180 | ENSP00000416040 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | UPF0606 protein KIAA1549; Belongs to the UPF0606 family | 0.505 |
C11orf95 | MAMLD1 | ENSP00000482180 | ENSP00000414517 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family | 0.650 |
C11orf95 | MKL2 | ENSP00000482180 | ENSP00000339086 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | MKL/myocardin-like protein 2; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation; Myocardin family | 0.612 |
C11orf95 | NFIB | ENSP00000482180 | ENSP00000370340 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | Nuclear factor 1 B-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication; Belongs to the CTF/NF-I family | 0.401 |
C11orf95 | RELA | ENSP00000482180 | ENSP00000384273 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | Rela proto-oncogene, nf-kb subunit; Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most a [...] | 0.681 |
C11orf95 | YAP1 | ENSP00000482180 | ENSP00000478927 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | Yes1 associated transcriptional regulator; Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn [...] | 0.614 |
C11orf95 | ZNF668 | ENSP00000482180 | ENSP00000442573 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | Zinc finger protein 668; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.448 |
EPN1 | C11orf95 | ENSP00000406209 | ENSP00000482180 | Epsin-1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis; Belongs to the epsin family | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | 0.450 |
FAM118B | C11orf95 | ENSP00000433343 | ENSP00000482180 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | 0.688 |
FAM118B | MAMLD1 | ENSP00000433343 | ENSP00000414517 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family | 0.710 |
FAM118B | YAP1 | ENSP00000433343 | ENSP00000478927 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | Yes1 associated transcriptional regulator; Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn [...] | 0.505 |
KIAA1549 | C11orf95 | ENSP00000416040 | ENSP00000482180 | UPF0606 protein KIAA1549; Belongs to the UPF0606 family | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | 0.505 |
MAMLD1 | C11orf95 | ENSP00000414517 | ENSP00000482180 | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | 0.650 |
MAMLD1 | FAM118B | ENSP00000414517 | ENSP00000433343 | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family | 0.710 |
MAMLD1 | YAP1 | ENSP00000414517 | ENSP00000478927 | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family | Yes1 associated transcriptional regulator; Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn [...] | 0.404 |
MKL2 | C11orf95 | ENSP00000339086 | ENSP00000482180 | MKL/myocardin-like protein 2; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation; Myocardin family | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | 0.612 |
NFIB | C11orf95 | ENSP00000370340 | ENSP00000482180 | Nuclear factor 1 B-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication; Belongs to the CTF/NF-I family | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | 0.401 |
RELA | C11orf95 | ENSP00000384273 | ENSP00000482180 | Rela proto-oncogene, nf-kb subunit; Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most a [...] | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 | 0.681 |