node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf95 | EZHIP | ENSP00000482180 | ENSP00000342680 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | EZH inhibitory protein; Inhibits PRC2/EED-EZH2 complex function thereby causing down- regulation of H3K27me3. In the PRC2/EED-EZH2 complex, interacts and inhibits EZH2 methyltransferase activity. | 0.535 |
C11orf95 | FAM118B | ENSP00000482180 | ENSP00000433343 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | 0.824 |
C11orf95 | FOXR2 | ENSP00000482180 | ENSP00000427329 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Forkhead box R2. | 0.451 |
C11orf95 | KIAA1549 | ENSP00000482180 | ENSP00000416040 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | UPF0606 protein KIAA1549; KIAA1549; Belongs to the UPF0606 family. | 0.597 |
C11orf95 | L1CAM | ENSP00000482180 | ENSP00000359077 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Neural cell adhesion molecule L1; Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. | 0.528 |
C11orf95 | MAMLD1 | ENSP00000482180 | ENSP00000414517 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family. | 0.747 |
C11orf95 | MN1 | ENSP00000482180 | ENSP00000304956 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Transcriptional activator MN1; Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). | 0.530 |
C11orf95 | MRTFB | ENSP00000482180 | ENSP00000459626 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. | 0.675 |
C11orf95 | RELA | ENSP00000482180 | ENSP00000384273 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kap [...] | 0.717 |
C11orf95 | YAP1 | ENSP00000482180 | ENSP00000478927 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncopro [...] | 0.618 |
EZHIP | C11orf95 | ENSP00000342680 | ENSP00000482180 | EZH inhibitory protein; Inhibits PRC2/EED-EZH2 complex function thereby causing down- regulation of H3K27me3. In the PRC2/EED-EZH2 complex, interacts and inhibits EZH2 methyltransferase activity. | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | 0.535 |
EZHIP | FAM118B | ENSP00000342680 | ENSP00000433343 | EZH inhibitory protein; Inhibits PRC2/EED-EZH2 complex function thereby causing down- regulation of H3K27me3. In the PRC2/EED-EZH2 complex, interacts and inhibits EZH2 methyltransferase activity. | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | 0.414 |
FAM118B | C11orf95 | ENSP00000433343 | ENSP00000482180 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | 0.824 |
FAM118B | EZHIP | ENSP00000433343 | ENSP00000342680 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | EZH inhibitory protein; Inhibits PRC2/EED-EZH2 complex function thereby causing down- regulation of H3K27me3. In the PRC2/EED-EZH2 complex, interacts and inhibits EZH2 methyltransferase activity. | 0.414 |
FAM118B | MAMLD1 | ENSP00000433343 | ENSP00000414517 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belongs to the mastermind family. | 0.822 |
FAM118B | RELA | ENSP00000433343 | ENSP00000384273 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kap [...] | 0.461 |
FAM118B | YAP1 | ENSP00000433343 | ENSP00000478927 | Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family. | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncopro [...] | 0.590 |
FOXR2 | C11orf95 | ENSP00000427329 | ENSP00000482180 | Forkhead box R2. | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | 0.451 |
FOXR2 | MN1 | ENSP00000427329 | ENSP00000304956 | Forkhead box R2. | Transcriptional activator MN1; Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable). | 0.445 |
KIAA1549 | C11orf95 | ENSP00000416040 | ENSP00000482180 | UPF0606 protein KIAA1549; KIAA1549; Belongs to the UPF0606 family. | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95. | 0.597 |