STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZCCHC18Zinc finger CCHC-type containing 18; Belongs to the ZCCHC12 family. (403 aa)    
Predicted Functional Partners:
PNMA8C
Paraneoplastic antigen-like protein 8C; PNMA family member 8C; Belongs to the PNMA family.
   
  
 0.638
KRBA2
KRAB-A domain containing 2.
      
 0.626
PNMA8A
Paraneoplastic antigen-like protein 8A; PNMA family member 8A.
  
  
 0.615
FANCM
Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...]
    
 
 0.532
BOD1L2
Biorientation of chromosomes in cell division protein 1-like 2; May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles; Belongs to the BOD1 family.
   
  
 0.517
LONRF3
LON peptidase N-terminal domain and ring finger 3.
   
  
 0.488
PNMA8B
Paraneoplastic antigen-like protein 8B; PNMA family member 8B.
   
  
 0.481
RASA4B
RAS p21 protein activator 4B.
    
 
 0.465
LAMA3
Laminin subunit alpha-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
    
 
 0.445
CIC
Protein capicua homolog; Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.
  
     0.423
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.