node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C2orf81 | CCDC154 | ENSP00000491941 | ENSP00000373828 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81. | Coiled-coil domain containing 154. | 0.655 |
C2orf81 | GOLGA6L7 | ENSP00000491941 | ENSP00000490318 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81. | Golgin subfamily A member 6-like protein 7; Golgin A6 family like 7; Belongs to the GOLGA6 family. | 0.571 |
C2orf81 | IQCN | ENSP00000491941 | ENSP00000376213 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81. | IQ motif containing N. | 0.648 |
C2orf81 | OR5J2 | ENSP00000491941 | ENSP00000310788 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81. | Olfactory receptor 5J2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.497 |
C2orf81 | ZNF658 | ENSP00000491941 | ENSP00000482540 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81. | Zinc finger protein 658; Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'- C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply. | 0.467 |
CCDC154 | C2orf81 | ENSP00000373828 | ENSP00000491941 | Coiled-coil domain containing 154. | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81. | 0.655 |
CCDC154 | GOLGA6L7 | ENSP00000373828 | ENSP00000490318 | Coiled-coil domain containing 154. | Golgin subfamily A member 6-like protein 7; Golgin A6 family like 7; Belongs to the GOLGA6 family. | 0.533 |
CCDC154 | IQCN | ENSP00000373828 | ENSP00000376213 | Coiled-coil domain containing 154. | IQ motif containing N. | 0.595 |
CCDC154 | OR5J2 | ENSP00000373828 | ENSP00000310788 | Coiled-coil domain containing 154. | Olfactory receptor 5J2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.447 |
CCDC154 | ZNF658 | ENSP00000373828 | ENSP00000482540 | Coiled-coil domain containing 154. | Zinc finger protein 658; Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'- C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply. | 0.434 |
CHD8 | TRIM28 | ENSP00000495240 | ENSP00000253024 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.432 |
CHD8 | ZNF658 | ENSP00000495240 | ENSP00000482540 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | Zinc finger protein 658; Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'- C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply. | 0.476 |
GOLGA6L7 | C2orf81 | ENSP00000490318 | ENSP00000491941 | Golgin subfamily A member 6-like protein 7; Golgin A6 family like 7; Belongs to the GOLGA6 family. | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81. | 0.571 |
GOLGA6L7 | CCDC154 | ENSP00000490318 | ENSP00000373828 | Golgin subfamily A member 6-like protein 7; Golgin A6 family like 7; Belongs to the GOLGA6 family. | Coiled-coil domain containing 154. | 0.533 |
GOLGA6L7 | IQCN | ENSP00000490318 | ENSP00000376213 | Golgin subfamily A member 6-like protein 7; Golgin A6 family like 7; Belongs to the GOLGA6 family. | IQ motif containing N. | 0.494 |
GOLGA6L7 | OR5J2 | ENSP00000490318 | ENSP00000310788 | Golgin subfamily A member 6-like protein 7; Golgin A6 family like 7; Belongs to the GOLGA6 family. | Olfactory receptor 5J2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.669 |
GOLGA6L7 | ZNF658 | ENSP00000490318 | ENSP00000482540 | Golgin subfamily A member 6-like protein 7; Golgin A6 family like 7; Belongs to the GOLGA6 family. | Zinc finger protein 658; Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'- C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply. | 0.621 |
IQCN | C2orf81 | ENSP00000376213 | ENSP00000491941 | IQ motif containing N. | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81. | 0.648 |
IQCN | CCDC154 | ENSP00000376213 | ENSP00000373828 | IQ motif containing N. | Coiled-coil domain containing 154. | 0.595 |
IQCN | GOLGA6L7 | ENSP00000376213 | ENSP00000490318 | IQ motif containing N. | Golgin subfamily A member 6-like protein 7; Golgin A6 family like 7; Belongs to the GOLGA6 family. | 0.494 |