node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCE1 | FTCDNL1 | ENSP00000296577 | ENSP00000482786 | ATP-binding cassette sub-family E member 1; Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'- linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly; Belongs to the ABC transporter superfamily. ABCE family. | Formiminotransferase cyclodeaminase N-terminal like. | 0.550 |
ABCE1 | YAE1 | ENSP00000296577 | ENSP00000223273 | ATP-binding cassette sub-family E member 1; Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'- linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly; Belongs to the ABC transporter superfamily. ABCE family. | Protein YAE1 homolog; The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. | 0.913 |
C2orf69 | FTCDNL1 | ENSP00000312770 | ENSP00000482786 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | Formiminotransferase cyclodeaminase N-terminal like. | 0.507 |
C2orf69 | MAIP1 | ENSP00000312770 | ENSP00000295079 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | 0.497 |
C2orf69 | SPATS2L | ENSP00000312770 | ENSP00000482515 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family. | 0.433 |
C2orf69 | TYW5 | ENSP00000312770 | ENSP00000346627 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family. | 0.598 |
FTCDNL1 | ABCE1 | ENSP00000482786 | ENSP00000296577 | Formiminotransferase cyclodeaminase N-terminal like. | ATP-binding cassette sub-family E member 1; Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'- linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly; Belongs to the ABC transporter superfamily. ABCE family. | 0.550 |
FTCDNL1 | C2orf69 | ENSP00000482786 | ENSP00000312770 | Formiminotransferase cyclodeaminase N-terminal like. | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | 0.507 |
FTCDNL1 | MAIP1 | ENSP00000482786 | ENSP00000295079 | Formiminotransferase cyclodeaminase N-terminal like. | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | 0.416 |
FTCDNL1 | SPATS2L | ENSP00000482786 | ENSP00000482515 | Formiminotransferase cyclodeaminase N-terminal like. | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family. | 0.431 |
FTCDNL1 | TYW5 | ENSP00000482786 | ENSP00000346627 | Formiminotransferase cyclodeaminase N-terminal like. | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family. | 0.610 |
FTCDNL1 | YAE1 | ENSP00000482786 | ENSP00000223273 | Formiminotransferase cyclodeaminase N-terminal like. | Protein YAE1 homolog; The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. | 0.751 |
FTCDNL1 | ZNF823 | ENSP00000482786 | ENSP00000340683 | Formiminotransferase cyclodeaminase N-terminal like. | Zinc finger protein 823; May be involved in transcriptional regulation. | 0.477 |
MAIP1 | C2orf69 | ENSP00000295079 | ENSP00000312770 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | 0.497 |
MAIP1 | FTCDNL1 | ENSP00000295079 | ENSP00000482786 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | Formiminotransferase cyclodeaminase N-terminal like. | 0.416 |
SPATS2L | C2orf69 | ENSP00000482515 | ENSP00000312770 | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family. | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | 0.433 |
SPATS2L | FTCDNL1 | ENSP00000482515 | ENSP00000482786 | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family. | Formiminotransferase cyclodeaminase N-terminal like. | 0.431 |
SPATS2L | TYW5 | ENSP00000482515 | ENSP00000346627 | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family. | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family. | 0.428 |
TYW5 | C2orf69 | ENSP00000346627 | ENSP00000312770 | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family. | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69. | 0.598 |
TYW5 | FTCDNL1 | ENSP00000346627 | ENSP00000482786 | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family. | Formiminotransferase cyclodeaminase N-terminal like. | 0.610 |