node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3orf52 | CLVS2 | ENSP00000399392 | ENSP00000275162 | TPA-induced transmembrane protein; Chromosome 3 open reading frame 52. | Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2). | 0.415 |
C3orf52 | ZNF343 | ENSP00000399392 | ENSP00000482819 | TPA-induced transmembrane protein; Chromosome 3 open reading frame 52. | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.402 |
CLVS2 | C3orf52 | ENSP00000275162 | ENSP00000399392 | Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2). | TPA-induced transmembrane protein; Chromosome 3 open reading frame 52. | 0.415 |
CLVS2 | ZNF343 | ENSP00000275162 | ENSP00000482819 | Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2). | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.408 |
STK35 | ZNF343 | ENSP00000370891 | ENSP00000482819 | Serine/threonine kinase 35. | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.417 |
SUMF2 | TMC3 | ENSP00000498402 | ENSP00000352413 | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | Transmembrane channel-like protein 3; Probable ion channel. | 0.449 |
SUMF2 | ZNF343 | ENSP00000498402 | ENSP00000482819 | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.462 |
TMC3 | SUMF2 | ENSP00000352413 | ENSP00000498402 | Transmembrane channel-like protein 3; Probable ion channel. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.449 |
TMC3 | ZNF343 | ENSP00000352413 | ENSP00000482819 | Transmembrane channel-like protein 3; Probable ion channel. | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.537 |
TRIM28 | ZNF133 | ENSP00000253024 | ENSP00000439427 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.784 |
TRIM28 | ZNF343 | ENSP00000253024 | ENSP00000482819 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.518 |
ZNF133 | TRIM28 | ENSP00000439427 | ENSP00000253024 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.784 |
ZNF133 | ZNF343 | ENSP00000439427 | ENSP00000482819 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.464 |
ZNF343 | C3orf52 | ENSP00000482819 | ENSP00000399392 | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | TPA-induced transmembrane protein; Chromosome 3 open reading frame 52. | 0.402 |
ZNF343 | CLVS2 | ENSP00000482819 | ENSP00000275162 | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2). | 0.408 |
ZNF343 | STK35 | ENSP00000482819 | ENSP00000370891 | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Serine/threonine kinase 35. | 0.417 |
ZNF343 | SUMF2 | ENSP00000482819 | ENSP00000498402 | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.462 |
ZNF343 | TMC3 | ENSP00000482819 | ENSP00000352413 | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transmembrane channel-like protein 3; Probable ion channel. | 0.537 |
ZNF343 | TRIM28 | ENSP00000482819 | ENSP00000253024 | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.518 |
ZNF343 | ZNF133 | ENSP00000482819 | ENSP00000439427 | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor. | 0.464 |