STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM106ATransmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family. (262 aa)    
Predicted Functional Partners:
TAF11L8
TATA-box-binding protein-associated factor 11-like 10; TATA-box binding protein associated factor 11 like 8.
      
 0.644
TAF11L7
TATA-box binding protein associated factor 11 like 7.
      
 0.644
TAF11L6
TATA-box binding protein associated factor 11 like 6.
      
 0.644
TAF11L4
TATA-box-binding protein-associated factor 11-like 4; TATA-box binding protein associated factor 11 like 4.
      
 0.644
TAF11L10
TATA-box binding protein associated factor 11 like 10.
      
 0.644
TAF11L3
TATA-box-binding protein-associated factor 11-like 3; TATA-box binding protein associated factor 11 like 3.
      
 0.644
TAF11L5
TATA-box binding protein associated factor 11 like 5.
      
 0.644
TAF11L2
Putative TAF11-like protein ENSP00000332601; TATA-box binding protein associated factor 11 like 2; Belongs to the TAF11 family.
      
 0.572
LINC02218
Long intergenic non-protein coding RNA 2218.
      
 0.541
FAM81B
Protein FAM81B; Family with sequence similarity 81 member B.
      
 0.442
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.