TMEM106A protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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co-expression

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gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM81B	TMEM106A	ENSP00000283357	ENSP00000483246	Protein FAM81B; Family with sequence similarity 81 member B.	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	0.506
HLA-DQA1	TMEM106A	ENSP00000339398	ENSP00000483246	Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family.	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	0.568
TAF11L10	TMEM106A	ENSP00000491873	ENSP00000483246	TATA-box binding protein associated factor 11 like 10.	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	0.578
TAF11L3	TAF11L4	ENSP00000492787	ENSP00000491494	TATA-box-binding protein-associated factor 11-like 3; TATA-box binding protein associated factor 11 like 3.	TATA-box-binding protein-associated factor 11-like 4; TATA-box binding protein associated factor 11 like 4.	0.904
TAF11L3	TAF11L8	ENSP00000492787	ENSP00000491174	TATA-box-binding protein-associated factor 11-like 3; TATA-box binding protein associated factor 11 like 3.	TATA-box-binding protein-associated factor 11-like 10; TATA-box binding protein associated factor 11 like 8.	0.904
TAF11L3	TMEM106A	ENSP00000492787	ENSP00000483246	TATA-box-binding protein-associated factor 11-like 3; TATA-box binding protein associated factor 11 like 3.	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	0.578
TAF11L4	TAF11L3	ENSP00000491494	ENSP00000492787	TATA-box-binding protein-associated factor 11-like 4; TATA-box binding protein associated factor 11 like 4.	TATA-box-binding protein-associated factor 11-like 3; TATA-box binding protein associated factor 11 like 3.	0.904
TAF11L4	TAF11L8	ENSP00000491494	ENSP00000491174	TATA-box-binding protein-associated factor 11-like 4; TATA-box binding protein associated factor 11 like 4.	TATA-box-binding protein-associated factor 11-like 10; TATA-box binding protein associated factor 11 like 8.	0.904
TAF11L4	TMEM106A	ENSP00000491494	ENSP00000483246	TATA-box-binding protein-associated factor 11-like 4; TATA-box binding protein associated factor 11 like 4.	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	0.578
TAF11L5	TMEM106A	ENSP00000492874	ENSP00000483246	TATA-box binding protein associated factor 11 like 5.	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	0.578
TAF11L6	TMEM106A	ENSP00000491385	ENSP00000483246	TATA-box binding protein associated factor 11 like 6.	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	0.578
TAF11L7	TMEM106A	ENSP00000491351	ENSP00000483246	TATA-box binding protein associated factor 11 like 7.	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	0.578
TAF11L8	TAF11L3	ENSP00000491174	ENSP00000492787	TATA-box-binding protein-associated factor 11-like 10; TATA-box binding protein associated factor 11 like 8.	TATA-box-binding protein-associated factor 11-like 3; TATA-box binding protein associated factor 11 like 3.	0.904
TAF11L8	TAF11L4	ENSP00000491174	ENSP00000491494	TATA-box-binding protein-associated factor 11-like 10; TATA-box binding protein associated factor 11 like 8.	TATA-box-binding protein-associated factor 11-like 4; TATA-box binding protein associated factor 11 like 4.	0.904
TAF11L8	TMEM106A	ENSP00000491174	ENSP00000483246	TATA-box-binding protein-associated factor 11-like 10; TATA-box binding protein associated factor 11 like 8.	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	0.578
TMEM106A	FAM81B	ENSP00000483246	ENSP00000283357	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	Protein FAM81B; Family with sequence similarity 81 member B.	0.506
TMEM106A	HLA-DQA1	ENSP00000483246	ENSP00000339398	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family.	0.568
TMEM106A	TAF11L10	ENSP00000483246	ENSP00000491873	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	TATA-box binding protein associated factor 11 like 10.	0.578
TMEM106A	TAF11L3	ENSP00000483246	ENSP00000492787	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	TATA-box-binding protein-associated factor 11-like 3; TATA-box binding protein associated factor 11 like 3.	0.578
TMEM106A	TAF11L4	ENSP00000483246	ENSP00000491494	Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration. Belongs to the TMEM106 family.	TATA-box-binding protein-associated factor 11-like 4; TATA-box binding protein associated factor 11 like 4.	0.578