SBK3 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C19orf85	RFPL4AL1	ENSP00000490220	ENSP00000345151	Uncharacterized protein C19orf85; Chromosome 19 open reading frame 85.	Ret finger protein like 4A like 1.	0.613
C19orf85	SBK3	ENSP00000490220	ENSP00000483467	Uncharacterized protein C19orf85; Chromosome 19 open reading frame 85.	Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.	0.519
C19orf85	ZNF580	ENSP00000490220	ENSP00000443957	Uncharacterized protein C19orf85; Chromosome 19 open reading frame 85.	Zinc finger protein 580; Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.	0.449
IQCA1L	MYADML2	ENSP00000482119	ENSP00000386702	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.	0.579
IQCA1L	P2RX6	ENSP00000482119	ENSP00000416193	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	P2X purinoceptor 6; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	0.472
IQCA1L	PHF24	ENSP00000482119	ENSP00000242315	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	PHD finger protein 24.	0.544
IQCA1L	SBK3	ENSP00000482119	ENSP00000483467	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.	0.577
IQCA1L	TMEM233	ENSP00000482119	ENSP00000403130	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	Transmembrane protein 233.	0.588
IQCA1L	YIPF7	ENSP00000482119	ENSP00000332772	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	Protein YIPF7; Yip1 domain family member 7; Belongs to the YIP1 family.	0.485
MYADML2	IQCA1L	ENSP00000386702	ENSP00000482119	Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	0.579
MYADML2	P2RX6	ENSP00000386702	ENSP00000416193	Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.	P2X purinoceptor 6; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	0.463
MYADML2	PHF24	ENSP00000386702	ENSP00000242315	Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.	PHD finger protein 24.	0.533
MYADML2	SBK3	ENSP00000386702	ENSP00000483467	Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.	Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.	0.575
MYADML2	TMEM233	ENSP00000386702	ENSP00000403130	Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.	Transmembrane protein 233.	0.530
MYADML2	YIPF7	ENSP00000386702	ENSP00000332772	Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.	Protein YIPF7; Yip1 domain family member 7; Belongs to the YIP1 family.	0.506
MYOC	SBK3	ENSP00000037502	ENSP00000483467	Myocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...]	Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.	0.504
P2RX6	IQCA1L	ENSP00000416193	ENSP00000482119	P2X purinoceptor 6; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.	0.472
P2RX6	MYADML2	ENSP00000416193	ENSP00000386702	P2X purinoceptor 6; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.	0.463
P2RX6	PHF24	ENSP00000416193	ENSP00000242315	P2X purinoceptor 6; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	PHD finger protein 24.	0.442
P2RX6	SBK3	ENSP00000416193	ENSP00000483467	P2X purinoceptor 6; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.	Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.	0.531