node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KRTAP10-7 | ZSCAN26 | ENSP00000476821 | ENSP00000485228 | Keratin-associated protein 10-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | 0.598 |
LRP4 | ZSCAN26 | ENSP00000367888 | ENSP00000485228 | Low-density lipoprotein receptor-related protein 4; Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the [...] | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | 0.453 |
NKAPL | ZKSCAN4 | ENSP00000345716 | ENSP00000366509 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis. | Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.722 |
NKAPL | ZSCAN26 | ENSP00000345716 | ENSP00000485228 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis. | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | 0.574 |
NPEPL1 | ZSCAN26 | ENSP00000348395 | ENSP00000485228 | Probable aminopeptidase NPEPL1; Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | 0.424 |
RRAGB | ZSCAN26 | ENSP00000262850 | ENSP00000485228 | Ras-related GTP-binding protein B; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. Belongs to the GTR/RAG GTP-binding protein family. | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | 0.437 |
TRIM11 | ZSCAN26 | ENSP00000284551 | ENSP00000485228 | E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation [...] | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | 0.446 |
VSIG10L | ZSCAN26 | ENSP00000335623 | ENSP00000485228 | V-set and immunoglobulin domain containing 10 like. | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | 0.453 |
ZKSCAN4 | NKAPL | ENSP00000366509 | ENSP00000345716 | Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family. | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis. | 0.722 |
ZKSCAN4 | ZSCAN26 | ENSP00000366509 | ENSP00000485228 | Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | 0.568 |
ZNF337 | ZSCAN26 | ENSP00000252979 | ENSP00000485228 | Zinc finger protein 337; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | 0.457 |
ZNF449 | ZSCAN26 | ENSP00000339585 | ENSP00000485228 | Zinc finger protein 449; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | 0.458 |
ZSCAN26 | KRTAP10-7 | ENSP00000485228 | ENSP00000476821 | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | Keratin-associated protein 10-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | 0.598 |
ZSCAN26 | LRP4 | ENSP00000485228 | ENSP00000367888 | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | Low-density lipoprotein receptor-related protein 4; Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the [...] | 0.453 |
ZSCAN26 | NKAPL | ENSP00000485228 | ENSP00000345716 | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis. | 0.574 |
ZSCAN26 | NPEPL1 | ENSP00000485228 | ENSP00000348395 | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | Probable aminopeptidase NPEPL1; Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. | 0.424 |
ZSCAN26 | RRAGB | ENSP00000485228 | ENSP00000262850 | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | Ras-related GTP-binding protein B; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. Belongs to the GTR/RAG GTP-binding protein family. | 0.437 |
ZSCAN26 | TRIM11 | ENSP00000485228 | ENSP00000284551 | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation [...] | 0.446 |
ZSCAN26 | VSIG10L | ENSP00000485228 | ENSP00000335623 | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | V-set and immunoglobulin domain containing 10 like. | 0.453 |
ZSCAN26 | ZKSCAN4 | ENSP00000485228 | ENSP00000366509 | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation. | Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.568 |