Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DEFB133Beta-defensin 133; Has antibacterial activity; Belongs to the beta-defensin family. (61 aa)    
Predicted Functional Partners:
DEFB113
Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.738
DEFB134
Beta-defensin 134; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.649
DEFB110
Beta-defensin 110; Has antibacterial activity.
   
 
  0.630
DEFB128
Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.589
GYPE
Glycophorin-E; This protein is a minor sialoglycoprotein in human erythrocyte membranes; Belongs to the glycophorin-A family.
   
    0.583
KRTAP22-2
Keratin-associated protein 22-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity); Belongs to the KRTAP type 20 family.
   
    0.571
AQP10
Aquaporin-10; [Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH. The channel is permeable to glycerol, especially when the cytosolic pH is acidified. Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation. May contribute to water transport in the intestine (Probable). Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
    0.546
DEFB135
Beta-defensin 135; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.543
DEFB115
Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.528
DEFB124
Beta-defensin 124; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.527
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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