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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DEFB133Beta-defensin 133; Has antibacterial activity; Belongs to the beta-defensin family. (61 aa)    
Predicted Functional Partners:
DEFB135
Beta-defensin 135; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.551
DEFB113
Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.551
DEFB110
Beta-defensin 110; Has antibacterial activity.
   
 
  0.535
DEFB106B
Beta-defensin 106; Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2. Belongs to the beta-defensin family.
   
 
  0.533
DEFB130B
Defensin beta 130B.
   
 
  0.530
DEFB121
Beta-defensin 121; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.529
DEFB114
Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality.
   
 
  0.523
DEFB128
Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.523
DEFB116
Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.523
DEFB115
Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family.
   
 
  0.523
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.