MTLN protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C12orf73	MTLN	ENSP00000367330	ENSP00000485216	Uncharacterized protein C12orf73; Chromosome 12 open reading frame 73.	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	0.570
C20orf204	MTLN	ENSP00000489747	ENSP00000485216	Uncharacterized protein C20orf204; Chromosome 20 open reading frame 204.	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	0.441
CYB5R3	MTLN	ENSP00000354468	ENSP00000485216	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	0.414
MRLN	MTLN	ENSP00000488748	ENSP00000485216	Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle.	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	0.576
MRLN	NBDY	ENSP00000488748	ENSP00000489583	Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle.	Negative regulator of P-body association; Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process.	0.548
MRLN	STRIT1	ENSP00000488748	ENSP00000489859	Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle.	Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).	0.858
MRPL33	MTLN	ENSP00000296102	ENSP00000485216	Mitochondrial ribosomal protein L33.	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	0.470
MRPL33	NDUFB3	ENSP00000296102	ENSP00000407336	Mitochondrial ribosomal protein L33.	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	0.781
MTLN	C12orf73	ENSP00000485216	ENSP00000367330	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	Uncharacterized protein C12orf73; Chromosome 12 open reading frame 73.	0.570
MTLN	C20orf204	ENSP00000485216	ENSP00000489747	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	Uncharacterized protein C20orf204; Chromosome 20 open reading frame 204.	0.441
MTLN	CYB5R3	ENSP00000485216	ENSP00000354468	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	0.414
MTLN	MRLN	ENSP00000485216	ENSP00000488748	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle.	0.576
MTLN	MRPL33	ENSP00000485216	ENSP00000296102	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	Mitochondrial ribosomal protein L33.	0.470
MTLN	NBDY	ENSP00000485216	ENSP00000489583	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	Negative regulator of P-body association; Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process.	0.555
MTLN	NDUFB3	ENSP00000485216	ENSP00000407336	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	0.488
MTLN	STRIT1	ENSP00000485216	ENSP00000489859	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).	0.500
NBDY	MRLN	ENSP00000489583	ENSP00000488748	Negative regulator of P-body association; Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process.	Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle.	0.548
NBDY	MTLN	ENSP00000489583	ENSP00000485216	Negative regulator of P-body association; Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process.	Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing mitochondrial reactive oxygen species. Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family.	0.555
NBDY	STRIT1	ENSP00000489583	ENSP00000489859	Negative regulator of P-body association; Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process.	Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).	0.451
NDUFB3	MRPL33	ENSP00000407336	ENSP00000296102	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	Mitochondrial ribosomal protein L33.	0.781