node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD9 | ZNF727 | ENSP00000286918 | ENSP00000485448 | Ankyrin repeat domain 9. | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.449 |
ASB7 | ZNF727 | ENSP00000328327 | ENSP00000485448 | Ankyrin repeat and SOCS box protein 7; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.422 |
C11orf1 | ZNF727 | ENSP00000260276 | ENSP00000485448 | UPF0686 protein C11orf1; Chromosome 11 open reading frame 1. | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.576 |
C16orf87 | ZNF727 | ENSP00000285697 | ENSP00000485448 | UPF0547 protein C16orf87; Chromosome 16 open reading frame 87; Belongs to the UPF0547 family. | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.571 |
DEFB115 | ZNF727 | ENSP00000383398 | ENSP00000485448 | Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family. | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.507 |
FAM135A | ZNF727 | ENSP00000410768 | ENSP00000485448 | Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family. | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.434 |
RBBP4 | TRIM28 | ENSP00000362592 | ENSP00000253024 | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.827 |
RBBP4 | ZNF727 | ENSP00000362592 | ENSP00000485448 | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.441 |
TRIM28 | RBBP4 | ENSP00000253024 | ENSP00000362592 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.827 |
TRIM28 | ZNF727 | ENSP00000253024 | ENSP00000485448 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.522 |
ZNF727 | ANKRD9 | ENSP00000485448 | ENSP00000286918 | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Ankyrin repeat domain 9. | 0.449 |
ZNF727 | ASB7 | ENSP00000485448 | ENSP00000328327 | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Ankyrin repeat and SOCS box protein 7; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | 0.422 |
ZNF727 | C11orf1 | ENSP00000485448 | ENSP00000260276 | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | UPF0686 protein C11orf1; Chromosome 11 open reading frame 1. | 0.576 |
ZNF727 | C16orf87 | ENSP00000485448 | ENSP00000285697 | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | UPF0547 protein C16orf87; Chromosome 16 open reading frame 87; Belongs to the UPF0547 family. | 0.571 |
ZNF727 | DEFB115 | ENSP00000485448 | ENSP00000383398 | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family. | 0.507 |
ZNF727 | FAM135A | ENSP00000485448 | ENSP00000410768 | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family. | 0.434 |
ZNF727 | RBBP4 | ENSP00000485448 | ENSP00000362592 | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.441 |
ZNF727 | TRIM28 | ENSP00000485448 | ENSP00000253024 | Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.522 |