STRINGSTRING
CERS1 protein (human) - STRING interaction network
"CERS1" - Embryonic growth/differentiation factor 1 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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CERS1Embryonic growth/differentiation factor 1; May mediate cell differentiation events during embryonic development; CERS class homeoboxes (372 aa)    
Predicted Functional Partners:
DEGS2
Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases (323 aa)
         
  0.926
KDSR
3-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family (332 aa)
         
  0.923
CERS6
Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes (392 aa)
           
  0.831
CERS2
Ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis; CERS class homeoboxes (380 aa)
           
  0.789
CERS4
Ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity); CERS class homeoboxes (394 aa)
           
  0.763
CERS5
Ceramide synthase 5; Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity); CERS class homeoboxes (392 aa)
           
  0.736
CERS3
Ceramide synthase 3; Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18-0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation; CERS class homeoboxes (383 aa)
           
  0.704
ACVR1C
Activin receptor type-1C; Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis (493 aa)
       
 
  0.666
CFC1
Cryptic protein; NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family (223 aa)
     
 
  0.650
MED13L
Mediator of RNA polymerase II transcription subunit 13-like; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may spe [...] (2210 aa)
           
  0.644
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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