node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCLAF3 | ZNF518A | ENSP00000369009 | ENSP00000485614 | BCLAF1 and THRAP3 family member 3; Belongs to the BCLAF1/THRAP3 family. | Zinc finger protein 518A; May be involved in transcriptional regulation. | 0.524 |
BRD3 | EHMT2 | ENSP00000305918 | ENSP00000379078 | Bromodomain-containing protein 3; Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). | Histone-lysine N-methyltransferase EHMT2; Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltr [...] | 0.694 |
BRD3 | ZNF518A | ENSP00000305918 | ENSP00000485614 | Bromodomain-containing protein 3; Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). | Zinc finger protein 518A; May be involved in transcriptional regulation. | 0.432 |
C5AR2 | ZNF518A | ENSP00000472620 | ENSP00000485614 | C5a anaphylatoxin chemotactic receptor 2; Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways; Belongs to the G-protein coupled receptor 1 family. | Zinc finger protein 518A; May be involved in transcriptional regulation. | 0.457 |
EHMT2 | BRD3 | ENSP00000379078 | ENSP00000305918 | Histone-lysine N-methyltransferase EHMT2; Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltr [...] | Bromodomain-containing protein 3; Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). | 0.694 |
EHMT2 | ZNF518A | ENSP00000379078 | ENSP00000485614 | Histone-lysine N-methyltransferase EHMT2; Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltr [...] | Zinc finger protein 518A; May be involved in transcriptional regulation. | 0.455 |
PROB1 | ZNF518A | ENSP00000416033 | ENSP00000485614 | Proline rich basic protein 1. | Zinc finger protein 518A; May be involved in transcriptional regulation. | 0.467 |
THOC1 | ZNF518A | ENSP00000261600 | ENSP00000485614 | THO complex subunit 1; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the T [...] | Zinc finger protein 518A; May be involved in transcriptional regulation. | 0.441 |
TMEM150B | ZCCHC2 | ENSP00000320757 | ENSP00000269499 | Modulator of macroautophagy TMEM150B; Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux. Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner. May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival. Belongs to the DRAM/TMEM150 family. | Zinc finger CCHC-type containing 2. | 0.420 |
TMEM150B | ZNF518A | ENSP00000320757 | ENSP00000485614 | Modulator of macroautophagy TMEM150B; Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux. Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner. May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival. Belongs to the DRAM/TMEM150 family. | Zinc finger protein 518A; May be involved in transcriptional regulation. | 0.466 |
U2SURP | ZNF518A | ENSP00000418563 | ENSP00000485614 | U2 snRNP-associated SURP motif-containing protein; U2 snRNP associated SURP domain containing; Belongs to the splicing factor SR family. | Zinc finger protein 518A; May be involved in transcriptional regulation. | 0.516 |
U2SURP | ZNF782 | ENSP00000418563 | ENSP00000419397 | U2 snRNP-associated SURP motif-containing protein; U2 snRNP associated SURP domain containing; Belongs to the splicing factor SR family. | Zinc finger protein 782; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.412 |
ZCCHC2 | TMEM150B | ENSP00000269499 | ENSP00000320757 | Zinc finger CCHC-type containing 2. | Modulator of macroautophagy TMEM150B; Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux. Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner. May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival. Belongs to the DRAM/TMEM150 family. | 0.420 |
ZCCHC2 | ZNF518A | ENSP00000269499 | ENSP00000485614 | Zinc finger CCHC-type containing 2. | Zinc finger protein 518A; May be involved in transcriptional regulation. | 0.573 |
ZNF518A | BCLAF3 | ENSP00000485614 | ENSP00000369009 | Zinc finger protein 518A; May be involved in transcriptional regulation. | BCLAF1 and THRAP3 family member 3; Belongs to the BCLAF1/THRAP3 family. | 0.524 |
ZNF518A | BRD3 | ENSP00000485614 | ENSP00000305918 | Zinc finger protein 518A; May be involved in transcriptional regulation. | Bromodomain-containing protein 3; Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). | 0.432 |
ZNF518A | C5AR2 | ENSP00000485614 | ENSP00000472620 | Zinc finger protein 518A; May be involved in transcriptional regulation. | C5a anaphylatoxin chemotactic receptor 2; Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways; Belongs to the G-protein coupled receptor 1 family. | 0.457 |
ZNF518A | EHMT2 | ENSP00000485614 | ENSP00000379078 | Zinc finger protein 518A; May be involved in transcriptional regulation. | Histone-lysine N-methyltransferase EHMT2; Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltr [...] | 0.455 |
ZNF518A | PROB1 | ENSP00000485614 | ENSP00000416033 | Zinc finger protein 518A; May be involved in transcriptional regulation. | Proline rich basic protein 1. | 0.467 |
ZNF518A | THOC1 | ENSP00000485614 | ENSP00000261600 | Zinc finger protein 518A; May be involved in transcriptional regulation. | THO complex subunit 1; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the T [...] | 0.441 |