PPT1 protein (human) - STRING interaction network

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PPT1

Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons ; Belongs to the palmitoyl-protein thioesterase family. (306 aa)

Predicted Functional Partners:

CLN3

0.995

CLN6

0.984

TPP1

0.981

CLN5

0.975

CLN8

0.963

PPT2

0.942

MECR

0.926

PSAP

0.920

MFSD8

0.904

KCTD7

0.903

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLN3	CLN5	ENSP00000454229	ENSP00000498772	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	0.991
CLN3	CLN6	ENSP00000454229	ENSP00000249806	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	CLN6 transmembrane ER protein.	0.981
CLN3	CLN8	ENSP00000454229	ENSP00000328182	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.	0.966
CLN3	KCTD7	ENSP00000454229	ENSP00000492240	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons.	0.749
CLN3	MFSD8	ENSP00000454229	ENSP00000493218	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients.	0.949
CLN3	PPT1	ENSP00000454229	ENSP00000493153	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons ; Belongs to the palmitoyl-protein thioesterase family.	0.995
CLN3	PPT2	ENSP00000454229	ENSP00000354608	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.	0.670
CLN3	TPP1	ENSP00000454229	ENSP00000299427	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.	0.962
CLN5	CLN3	ENSP00000498772	ENSP00000454229	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	0.991
CLN5	CLN6	ENSP00000498772	ENSP00000249806	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	CLN6 transmembrane ER protein.	0.992
CLN5	CLN8	ENSP00000498772	ENSP00000328182	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.	0.978
CLN5	KCTD7	ENSP00000498772	ENSP00000492240	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons.	0.871
CLN5	MFSD8	ENSP00000498772	ENSP00000493218	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients.	0.933
CLN5	PPT1	ENSP00000498772	ENSP00000493153	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons ; Belongs to the palmitoyl-protein thioesterase family.	0.975
CLN5	PPT2	ENSP00000498772	ENSP00000354608	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins.	0.762
CLN5	TPP1	ENSP00000498772	ENSP00000299427	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.	0.799
CLN6	CLN3	ENSP00000249806	ENSP00000454229	CLN6 transmembrane ER protein.	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	0.981
CLN6	CLN5	ENSP00000249806	ENSP00000498772	CLN6 transmembrane ER protein.	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	0.992
CLN6	CLN8	ENSP00000249806	ENSP00000328182	CLN6 transmembrane ER protein.	Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.	0.981
CLN6	KCTD7	ENSP00000249806	ENSP00000492240	CLN6 transmembrane ER protein.	BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons.	0.881

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